Evidence map›Paper›PMID 34710995›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2021

Evaluation of Silver Nanoparticles Caffeic Acid Complex Compound as New Potential Therapeutic Agent against Cancer Incidence in Mice.

Tahany Saad Abdelwahab, Rania Ellisy Abdelhamed, Eman Noaman Ali, Nahla Ahmed Mansour, Mohga Shafik Abdalla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Adjuvant Properties of Caffeic Acid in Cancer Treatment.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tahany Saad AbdelwahabDepartment of chemistry, Faculty of Science, Helwan University, Egypt.ORCID 0000-0001-6442-9197
Rania Ellisy AbdelhamedDepartment of chemistry, Faculty of Science, Helwan University, Egypt.
Eman Noaman AliDepartment of Biochemistry, Radiation Biology Department, National Center for Radiation Research and Technology, Egypt.
Nahla Ahmed MansourDepartment of Organic Chemistry, Petrochemical Department, Egyptian Petroleum Research Institute, Egypt.
Mohga Shafik AbdallaDepartment of chemistry, Faculty of Science, Helwan University, Egypt.ORCID 0000-0002-8805-6150
Helwan University · EGEgyptian Petroleum Research Institute · EGNational Water Research Center · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present work was designed to study the effect of new conjugated caffeic and folic acid with silver nanoparticles with definite molecular size applied with and without gamma radiation exposure, as an antitumor agent against experimentally induced Ehrlich tumor and attempted to identify their potential molecular mechanisms of action throughout determination of anti-tumor activities using MTT cytotoxic assay against two human carcinoma cell lines in vitro, such as apoptosis analysis by flow cytometry through caspase-8, caspase-3 and TNF determination in vivo. MATERIALS AND

methodsAdult female albino mice were used and divided into five groups. Animals were sacrificed and the following parameters were estimated, glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) in blood in addition to caspase8, caspase 3 and tumor necrosis factor (TNF) of tumor tissue, liver and kidney function also measured in plasma. The tumor specimens were processed for histopathological examination.

resultsNano-silver folate caffeic (NSFC) complex compound treatment resulted in growth inhibition in Ehrlich solid tumor, Hep-G2, and MCF-7 cells (IC50 0.062 mg, 7.70 µM, and 14.50 µM, respectively). Flow cytometric analysis revealed that (NSFC) with radiation IR had apoptotic effects at caspases 8 (Mean±SD) (49.4±14), caspase3 (39.97±9.75), and TNF (40.1±3.4) more than any other groups. Those disturbances were found to be associated with a kinetic induction of apoptosis and showed modulation of the antioxidant system {glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) which were 60.70±0.80, 26.73±0.80, 39.52±0.58 respectively}at the group which took (NSFC+IR), besides its high percentage of necrotic cells by histopathological studies. In conclusion, the present study showed that the treatment of (NSFC) exhibits very efficient oncolytic activity in delaying tumor growth in mice bearing Ehrlich Solid Carcinoma (ESC) and the mechanisms underlying the inhibitory effect of the present compound involve both an apoptotic effect against Hep-G2 and MCF-7 cells and modulation of antioxidant system.

Indexed as

AnimalsAnticarcinogenic AgentsApoptosisBreast NeoplasmsCaffeic AcidsCarcinoma, Ehrlich TumorCaspase 3Caspase 8FemaleFolic AcidGlutathioneGlutathione PeroxidaseHep G2 CellsHumansLiver NeoplasmsMCF-7 CellsAnticarcinogenic Agentscaffeic acidCaffeic AcidsCaspase 3Caspase 8Folic AcidGlutathioneGlutathione PeroxidaseNanoconjugatesSilverSuperoxide DismutaseTumor Necrosis FactorsApoptosisConjugated caffeic and folic acidRadiationSilver nanoparticlesTumor

Identifiers

PMID34710995
PMCPMC8858226
OpenAlexW3210745801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.