ReviewPhysics in medicine and biology2021
Adaptive proton therapy.
Review in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Technical Considerations on Proton Therapy in NRG's Multi-Institutional Clinical Trials.International journal of radiation oncology, biology, physics · 2026Guideline
- Review
- A two-stage framework for fast proton spot map generation in pencil beam scanning prostate SBRT planning.Medical physics · 2026Article
- MR-Guided Adaptive Radiotherapy in Lung Cancer: Current Landscape and Future Directions.Cancers · 2026Review
- A novel approach for spot boosting selection and treatment plan optimization to enhance prompt gamma monitoring of proton therapy.Physics and imaging in radiation oncology · 2026Article
- Temporal trends and evolution of photon and proton radiotherapy research.Radiation oncology journal · 2026Article
- Offline Plan Adaptation in Robustly Optimized CBCT-Guided Pencil Beam Scanning Proton Beam Therapy: Lessons From a Real-World Cohort.Advances in radiation oncology · 2026Article
- Radioactive ion beam range adaptation in mouse tumors using in-beam PET.Communications medicine · 2026Article
- Feasibility of in-vivo 4D prompt-gamma treatment verification in proton therapy for pancreatic cancer.Physics and imaging in radiation oncology · 2026Article
- Towards a shuttle-based workflow for daily online magnetic resonance imaging-guided particle therapy: Anatomical robustness and organ variability in the female pelvis.Technical innovations & patient support in radiation oncology · 2026Article
- Mid-range arc therapy for efficient and RBE-robust proton treatment.Physics in medicine and biology · 2026Article
- Assessing the quality of deformable image registration in magnetic resonance image guided carbon ion liver radiotherapy with an anthropomorphic phantom.Physics and imaging in radiation oncology · 2026Article
- Retrospective analysis of adaptation frequencies and factors in offline in offline adaptive proton therapy.Journal of applied clinical medical physics · 2026Article
- Treatment planning comparison of proton arc therapy and intensity modulated proton therapy for synchronous bilateral breast or chest wall and regional nodal irradiation.Physics and imaging in radiation oncology · 2026Article
- Terminology Proposal for Adaptive Particle Therapy Classification and Strategies.International journal of particle therapy · 2026Article
- An Artificial Intelligence Dose Engine for Fast Carbon Ion Treatment Planning.International journal of particle therapy · 2026Article
- Defining a Quantitative Threshold for Adaptive Re-planning using a Percentile-based Scoring System.International journal of particle therapy · 2026Article
- Enhancing CBCT-based CT synthesis using planning MRI in adaptive proton therapy for head cancer: A deep learning approach.Journal of applied clinical medical physics · 2025Article
- Target Coverage Improvement With Dose Matching in Carbon-Ion Radiation Therapy for Pancreatic Cancer.International journal of particle therapy · 2025Article
- Time-saving potential of daily online adaptive proton therapy for head and neck cancers by reducing number of beams.Physics and imaging in radiation oncology · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Radiation therapy treatments are typically planned based on a single image set, assuming that the patient's anatomy and its position relative to the delivery system remains constant during the course of treatment. Similarly, the prescription dose assumes constant biological dose-response over the treatment course. However, variations can and do occur on multiple time scales. For treatment sites with significant intra-fractional motion, geometric changes happen over seconds or minutes, while biological considerations change over days or weeks. At an intermediate timescale, geometric changes occur between daily treatment fractions. Adaptive radiation therapy is applied to consider changes in patient anatomy during the course of fractionated treatment delivery. While traditionally adaptation has been done off-line with replanning based on new CT images, online treatment adaptation based on on-board imaging has gained momentum in recent years due to advanced imaging techniques combined with treatment delivery systems. Adaptation is particularly important in proton therapy where small changes in patient anatomy can lead to significant dose perturbations due to the dose conformality and finite range of proton beams. This review summarizes the current state-of-the-art of on-line adaptive proton therapy and identifies areas requiring further research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.