Evidence map›Paper›PMID 34710776›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2022

Lipid Levels and Short-Term Risk of Recurrent Brain Infarcts in Symptomatic Intracranial Stenosis.

Shyam Prabhakaran, David S Liebeskind, George Cotsonis, Azhar Nizam, Edward Feldmann, Rajbeer S Sangha, Iszet Campo-Bustillo, Jose G Romano, MYRIAD Investigators

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In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Statin initiation and early stroke recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial (POINT) trial population.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shyam PrabhakaranThe University of Chicago, Chicago, IL, USA. Electronic address: shyam1@uchicago.edu.
David S LiebeskindUniversity of California at Los Angeles, Los Angeles, CA, USA.
George CotsonisEmory University, Atlanta, GA, USA.
Azhar NizamEmory University, Atlanta, GA, USA.
Edward FeldmannThe University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
Rajbeer S SanghaUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Iszet Campo-BustilloUniversity of Miami, Miami, FL, USA.
Jose G RomanoUniversity of Miami, Miami, FL, USA.
MYRIAD Investigators

Funding

Mechanisms of Early Recurrence in Intracranial Atherosclerotic DiseaseR01NS084288 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIEBESKIND, DAVID SIGMUND, PRABHAKARAN, SHYAM · 2014 to 2018
$3.0M
NINDS NIH HHS R01 NS084288
6 · The paper itself

Abstract

objectivesHyperlipidemia is a strong risk factor for intracranial atherosclerotic disease (ICAD) and clinical stroke recurrence. We explored the effect of serum lipid levels on subclinical infarct recurrence in the Mechanisms of earlY Recurrence in Intracranial Atherosclerotic Disease (MYRIAD) study. MATERIALS AND

methodsWe included enrolled MYRIAD patients with lipid measurements and brain MRI at baseline and brain MRI at 6-8 weeks. Infarct recurrence was defined as new infarcts in the territory of the symptomatic artery on brain MRI at 6-8 weeks compared to baseline brain MRI. We assessed the association between baseline total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels and recurrent infarct at 6-8 weeks using multivariable logistic regression.

resultsAmong 74 patients (mean age 64.2±12.9 years, 59.5% were white, 60.8% men), 20 (27.0%) had new or recurrent infarcts. Mean HDL-C (37.2 vs. 43.9 mg/dL, P=0.037) was lower and TG (113.5 vs. 91.3 mg/dL, P=0.008) was higher while TC (199.8 vs. 174.3 mg/dL, P=0.061) and LDL-C (124.3 vs. 101.2 mg/dL, P=0.053) were nominally higher among those with recurrent infarcts than those without. LDL-C (adj. OR 1.022, 95% CI 1.004-1.040, P=0.015) and TG (adj. OR 1.009, 95% CI 1.001-1.016, P=0.021) were predictors of recurrent infarct at 6-8 weeks adjusting for other clinical and imaging factors.

conclusionsBaseline cholesterol markers can predict early infarct recurrence in patients with symptomatic ICAD. More intensive and rapid lipid lowering drugs may be required to reduce risk of early recurrence.

Indexed as

Brain InfarctionIntracranial ArteriosclerosisLipidsAgedBiomarkersCholesterolCholesterol, HDLCholesterol, LDLFemaleHumansMaleMiddle AgedPredictive Value of TestsRecurrenceRisk FactorsTriglyceridesBiomarkersCholesterolCholesterol, HDLCholesterol, LDLLipidsTriglyceridesCholesterolMagnetic resonance imagingStatinStroke

Identifiers

PMID34710776
PMCPMC8766886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.