Evidence map›Paper›PMID 34710444›Full record

ArticleLife sciences2022

Persistent exercise fatigue and associative learning deficits in combination with transient glucose dyshomeostasis in a mouse model of Gulf War Illness.

Elena V Kozlova, Bruno Carabelli, Anthony E Bishay, Maximillian E Denys, Devi B Chinthirla, Jasmin D Tran, Ansel Hsiao, Nicole I Zur Nieden, Margarita C Currás-Collazo

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Article in Life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Elena V KozlovaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA; Neuroscience Graduate Program, University of California, Riverside, CA, USA.
Bruno CarabelliDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Anthony E BishayDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Maximillian E DenysDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Devi B ChinthirlaDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Jasmin D TranDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Ansel HsiaoDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA, USA.
Nicole I Zur NiedenDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA.
Margarita C Currás-CollazoDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, CA, USA. Electronic address: mcur@ucr.edu.
University of California, Riverside · US

Funding

Vibrio cholerae antinitrosative stress defenses and gut microbiome interactionR01AI157106 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HSIAO, ANSEL, ZHU, JUN · 2020 to 2024
$4.0M
Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
NIAID NIH HHS R01 AI157106NIGMS NIH HHS R35 GM124724
6 · The paper itself

Abstract

aimsTo characterize exercise fatigue, metabolic phenotype and cognitive and mood deficits correlated with brain neuroinflammatory and gut microbiome changes in a chronic Gulf War Illness (GWI) mouse model. The latter have been described in an accompanying paper [1]. MAIN

methodsAdult male C57Bl/6N mice were exposed for 28 days (5 days/week) to pyridostigmine bromide: 6.5 mg/kg, b.i.d., P.O. (GW1) or 8.7 mg/kg, q.d., P.O. (GW2); topical permethrin (1.3 mg/kg in 100% DMSO) and N,N-diethyl-meta-toluamide (DEET 33% in 70% EtOH) and restraint stress (5 min). Exercise, metabolic and behavioral endpoints were compared to sham stress control (CON/S). KEY

findingsRelative to CON/S, GW2 presented persistent exercise intolerance (through post-treatment (PT) day 161), deficient associative learning/memory, and transient insulin insensitivity. In contrast to GW2, GW1 showed deficient long-term object recognition memory, milder associative learning/memory deficit, and behavioral despair. SIGNIFICANCE: Our findings demonstrate that GW chemicals dose-dependently determine the presentation of exercise fatigue and severity/type of cognitive/mood-deficient phenotypes that show persistence. Our comprehensive mouse model of GWI recapitulates the major multiple symptom domains characterizing GWI, including fatigue and cognitive impairment that can be used to more efficiently develop diagnostic tests and curative treatments for ill Gulf War veterans.

Indexed as

FatigueLearning DisabilitiesPersian Gulf SyndromeAnimalsDisease Models, AnimalGlucoseHumansMaleMicePyridostigmine BromideGlucosePyridostigmine BromideCentral nervous systemCognitive impairmentDepressionDiabetesInsulin insensitivityMoodNovel object recognition memoryPassive avoidance learning

Identifiers

PMID34710444
PMCPMC9053767
OpenAlexW3208438067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.