ArticleBrain and behavior2021
Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- A structural network fingerprint of mild traumatic brain injury: a multi-study synthesis of T1-weighted MRI abnormalities.Frontiers in human neuroscience · 2026Pooled it
- Systematic review and meta-analysis of the impact of loss of consciousness on clinical outcomes in mild traumatic brain injury.Scientific reports · 2025Pooled it
- Charcot-Marie-Tooth disease and related neuropathies.Nature reviews. Disease primers · 2026Review
- Time course of functional and structural brain network changes after mild traumatic brain injury.Brain communications · 2026Article
- Changes in brain morphology over the first year in adult mixed-mechanism mild traumatic brain injury: the role of injury severity factors.NeuroImage. Clinical · 2026Article
- Regional and Global Changes in Brain Structure 1-Year Post Pediatric "Mild" Traumatic Brain Injury.Annals of neurology · 2025Article
- Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project.Brain : a journal of neurology · 2024Article
- Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study.The journal of headache and pain · 2024Article
- Significant Acceleration of Regional Brain Aging and Atrophy After Mild Traumatic Brain Injury.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Persistence of Hyper-Ramified Microglia in Porcine Cortical Gray Matter after Mild Traumatic Brain Injury.Biomedicines · 2023Article
- Prospective Study of Gray Matter Atrophy Following Pediatric Mild Traumatic Brain Injury.Neurology · 2023Article
- Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury.Brain and behavior · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic gray matter (GM) atrophy is a known consequence of moderate and severe traumatic brain injuries but has not been consistently shown in mild traumatic brain injury (mTBI). The aim of this study was to investigate the longitudinal effect of uncomplicated mTBI on the brain's GM and white matter (WM) from 6 weeks to 12 months after injury. Voxel-based-morphometry (VBM) was computed with the T1-weighted images of 48 uncomplicated mTBI patients and 37 orthopedic controls. Over the period from 6 weeks to 12 months, only patients who experienced uncomplicated mTBI, but not control participants, showed significant GM decrease predominantly in the right hemisphere along the GM-CSF border in lateral and medial portions of the sensorimotor cortex extending into the rolandic operculum, middle frontal gyrus, insula, and temporal pole. Additionally, only mTBI patients, but not controls, experienced significant WM decrease predominantly in the right hemisphere in the superior fasciculus longitudinalis, arcuate fasciculus, and cortical-pontine tracts as well as a significant WM increase in left arcuate fasciculus and left capsula extrema. We did not observe any significant change in the controls for the same time interval or any significant group differences in GM and WM probability at each of the two timepoints. This suggests that the changes along the brain tissue borders observed in the mTBI group represent a reorganization associated with subtle microscopical changes in intracortical myelin and not a direct degenerative process as a result of mTBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.