Evidence map›Paper›PMID 34710206›Full record

ArticleNanoscale2021

Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases.

Xinyue Chen, Russell Hughes, Nic Mullin, Rhoda J Hawkins, Ingunn Holen, Nicola J Brown, Jamie K Hobbs

Abstract read
In one paragraph

Article in Nanoscale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Exploring bone-tumor interactions through 3DJournal of bone oncology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Biomechanical Aspects in Bone Tumor Engineering.Tissue engineering. Part B, Reviews · 2024
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyue ChenDepartment of Physics and Astronomy, University of Sheffield, S3 7RH, UK. jamie.hobbs@sheffield.ac.uk.ORCID http://orcid.org/0000-0001-6987-5540
Russell HughesDepartment of Oncology and Metabolism, University of Sheffield, S10 2RX, UK.
Nic MullinDepartment of Physics and Astronomy, University of Sheffield, S3 7RH, UK. jamie.hobbs@sheffield.ac.uk.
Rhoda J HawkinsDepartment of Physics and Astronomy, University of Sheffield, S3 7RH, UK. jamie.hobbs@sheffield.ac.uk.
Ingunn HolenDepartment of Oncology and Metabolism, University of Sheffield, S10 2RX, UK.
Nicola J BrownDepartment of Oncology and Metabolism, University of Sheffield, S10 2RX, UK.ORCID http://orcid.org/0000-0002-2100-1905
Jamie K HobbsDepartment of Physics and Astronomy, University of Sheffield, S3 7RH, UK. jamie.hobbs@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-5872-1404

Funding

Cancer Research UK 21082
6 · The paper itself

Abstract

Mechanically dependent processes are essential in cancer metastases. However, reliable mechanical characterization of metastatic cancer remains challenging whilst maintaining the tissue complexity and an intact sample. Using atomic force microscopy, we quantified the micro-mechanical properties of relatively intact metastatic breast tumours and their surrounding bone microenvironment isolated from mice, and compared with other breast cancer models both

Indexed as

Bone NeoplasmsBreast NeoplasmsAnimalsElastic ModulusFemaleHumansMiceMicroscopy, Atomic ForceTumor MicroenvironmentViscosity

Identifiers

PMID34710206
PMCPMC8584157

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.