SynthesisPloS one2021
The prevalence of malnutrition and its effects on the all-cause mortality among patients with heart failure: A systematic review and meta-analysis.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- High-Protein Dietary Interventions in Heart Failure: A Systematic Review of Clinical and Functional Outcomes.Nutrients · 2025Pooled it
- CONUT Score as a Predictor of Mortality Risk in Acute and Chronic Heart Failure: A Meta-Analytic Review.Nutrients · 2025Pooled it
- Malnutrition Predicts Adverse Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Anatolian journal of cardiology · 2023Pooled it
- Trial
- Prognostic Significance of Nutritional Scores in Patients With Heart Failure: Insights From the PARAGON-HF Trial.Journal of the American Heart Association · 2025Trial
- Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure.Asia Pacific journal of clinical nutrition · 2026Article
- Combined GLIM-defined malnutrition and sarcopenia and the risk of 2-year mortality in adults with heart failure: A FRAGILE-HF study post hoc analysis.JPEN. Journal of parenteral and enteral nutrition · 2026Observational
- Impact of Preoperative Malnutrition and Sarcopenia on Clinical Outcomes After Transcatheter Aortic Valve Replacement.Circulation reports · 2026Article
- Perioperative nutritional status in cardiac surgery patients: a multicenter observational study in Shanghai, China.General thoracic and cardiovascular surgery · 2026Observational
- Associations Between Controlling Nutritional Status and Allostatic Load With Heart Failure Across Different Depressive States: A Cross-Sectional Study Using NHANES 2005-2018 Data.Reviews in cardiovascular medicine · 2026Article
- Association of the C-reactive protein-albumin-lymphocyte index with heart failure prevalence and mortality risk in older adults with hypertension: A cohort study.The Journal of international medical research · 2026Article
- Modified nutrition risk in critically ill (mNUTRIC) score on admission and mortality in acute heart failure patients admitted to the cardiac intensive care unit.Heart and vessels · 2026Article
- Underlying Mechanisms of Osteoporosis in the Context of Multimorbidity: Clinical Challenges and Management Strategies.Nutrients · 2026Review
- Effects of Enhanced Nutritional Care in Heart Failure - A Systematic Review and Meta-Analysis.Circulation reports · 2026Review
- Timing, continuity, and energy dose of oral nutritional supplements in older coronary care unit patients: associations with prognostic nutritional index trajectory and hospitalization burden.Frontiers in nutrition · 2026Article
- Factors Associated with Malnutrition in Thai Patients with Heart Failure: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
- The C-reactive protein-to-body mass index ratio predicts prognosis in patients with different types of heart failure.Open medicine (Warsaw, Poland) · 2026Article
- Prognostic Impact of Annual Changes in the Geriatric Nutritional Risk Index in Malnourished Patients With Heart Failure.Circulation reports · 2025Article
- Article
- Multiprofessional Interventions for Frailty in Patients with Heart Failure: A Comprehensive Review.Current heart failure reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMalnutrition has a high occurrence in patients with chronic heart failure (CHF). The prevalence of malnutrition and its impact on all-cause mortality in patients with CHF were assessed using a meta-analysis.
methodsPubMed, Embase, the Cochrane Library, Web of Science, Medline, CBM, CNKI, WANFANG DATA, and VIP databases were searched to collect cross-sectional and cohort studies on malnutrition, and the prevalence and all-cause mortality of patients with CHF were determined. The time of retrieval was from the database establishment to May 2021. Two researchers independently performed screening of the literature, data extraction and assessed the risk of bias in the included studies. Then Stata 16.0 software was used for meta-analysis.
resultsA total of 10 cross-sectional and 21 cohort studies were included, including 12537 patients with CHF. A meta-analysis demonstrated that the total prevalence of malnutrition in patients with heart failure was 46% (95% confidence interval [CI]: 0.43, 0.49). Compared to patients with non-malnutrition, malnutrition increased the risk of all-cause mortality in patients with CHF (hazard ratio = 2.15, 95% CI [1.89, 2.45], P < 0.05). DISCUSSION: Current evidence suggests that the prevalence of malnutrition is high among patients with CHF. The risk of all-cause mortality in such patients can be increased by malnutrition. Therefore, the risk of malnutrition in patients with CHF should be considered to reduce the occurrence of adverse clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.