Evidence map›Paper›PMID 34709649›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Humanized Mice for the Study of Dengue Disease Pathogenesis: Biological Assays.

Hernando Gutierrez-Barbosa, Sandra Medina-Moreno, Harry Davis, Joseph Bryant, Joel V Chua, Juan C Zapata

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hernando Gutierrez-BarbosaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Sandra Medina-MorenoAmerican Gene Technologies International, Rockville, MD, USA.
Harry DavisInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Joseph BryantInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Joel V ChuaInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Juan C ZapataAmerican Gene Technologies International, Rockville, MD, USA. jzapata@americangene.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is one of the most prevalent infectious diseases around the world, present in all continents and mainly affecting developing countries. With few tools to fight and study this disease, it is imperative to have reliable animal models that not only recapitulate human disease but also contain human components to understand the pathogenic mechanism and immune responses, allowing the development of new treatments and vaccines against dengue. Humanized mice are a significant advance in the development of in vivo models to understanding the relation of the human immune system and target organs such as the liver during the infection by dengue virus, allowing basic and preclinical research. In this chapter, we describe the use of humanized NSG mice (huNSG) for the study of dengue disease. The first model describes reconstitution of the human immune system by transplanting human CD34

Indexed as

DengueDengue VirusAnimalsBiological AssayDisease Models, AnimalMiceMice, SCIDDengue mouse modelsDENVDrug developmentHumanized miceImmune responsePathogenesisVaccine

Identifiers

PMID34709649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.