Evidence map›Paper›PMID 34709566›Full record

ArticleTransgenic research2022

Uncoupling protein 1 knockout aggravates isoproterenol-induced acute myocardial ischemia via AMPK/mTOR/PPARα pathways in rats.

Daorong Hou, Heling Fu, Yuan Zheng, Dan Lu, Yuanwu Ma, Yuan Yin, Lianfeng Zhang, Dan Bao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transgenic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daorong Hou *Key laboratory of the model animal, Animal Core Facility of Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China.
Heling Fu *Key laboratory of the model animal, Animal Core Facility of Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China.
Yuan ZhengKey laboratory of the model animal, Animal Core Facility of Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China.
Dan LuKey laboratory of human disease comparative medicine, NHFPC, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing, 100021, China.
Yuanwu MaKey laboratory of human disease comparative medicine, NHFPC, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing, 100021, China.
Yuan YinKey laboratory of the model animal, Animal Core Facility of Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China.
Lianfeng ZhangKey laboratory of human disease comparative medicine, NHFPC, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medical Center, Peking Union Medical College, Beijing, 100021, China. Zhanglf@cnilas.org.
Dan BaoKey laboratory of the model animal, Animal Core Facility of Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China. jndwbaodan@njmu.edu.cn.ORCID 0000-0002-0221-9140
Model Animal Research Center · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uncoupling protein 1 (UCP1) was found exclusively in the inner membranes of the mitochondria of brown adipose tissue (BAT). We found that UCP1 was also expressed in heart tissue and significantly upregulated in isoproterenol (ISO)-induced acute myocardial ischemia (AMI) rat model. The present study is to determine the underlying mechanism involved in the UCP1 upregulation in ISO-induced AMI rat model. The Ucp1

Indexed as

AMP-Activated Protein KinasesMyocardial IschemiaAnimalsIsoproterenolMammalsMyocardiumPeroxisome ProliferatorsPPAR alphaRatsRats, Sprague-DawleySuperoxide DismutaseTOR Serine-Threonine KinasesUncoupling Protein 1AMP-Activated Protein KinasesIsoproterenolmTOR protein, ratPeroxisome ProliferatorsPPAR alphaSuperoxide DismutaseTOR Serine-Threonine KinasesUncoupling Protein 1Acute myocardial ischemiaLV remodelingOxidative stressUCP1

Identifiers

PMID34709566
PMCPMC8821478
OpenAlexW3208299565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.