Evidence map›Paper›PMID 34709518›Full record

ArticleBulletin of experimental biology and medicine2021

H1-Receptor Antagonist Olopatadine Inhibits MUC5AC Secretion by Conjunctival Goblet Cells.

M He, W Qin, Y Wu, X Wang, Y Wang, X Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

M HeDepartment of Ophthalmology, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, China. heminzzzz@hotmail.com.
W QinDepartment of Ophthalmology, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, China.
Y WuDepartment of Ophthalmology, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, China.
X WangDepartment of Ophthalmology, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, China.
Y WangBayi Children's Hospital Affiliated to PLA Army General Hospital, Beijing, China.
X WangDepartment of Pathology, Shanxi Medical University, Taiyuan, Shanxi, China.
Shanxi Medical University · CNSecond Hospital of Shanxi Medical University · CNBayi Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study examined the effect of H1-receptor antagonist olopatadine on the secretory function of cultured rat conjunctival goblet cells (CGC) assessed by enzyme-linked lectin assay employing UEA-I lectin. The level of mRNA for membrane-bound protein MUC16 in histaminestimulated CGC was assayed by reverse transcription PCR in the control and after preliminary application of olopatadine. The intracellular calcium concentration [Ca

Indexed as

AnimalsCalciumCations, DivalentConjunctivaGene ExpressionGoblet CellsHistamineHistamine H1 AntagonistsMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mucin 5ACOlopatadine HydrochloridePhosphorylationPrimary Cell CultureRatsCalciumCations, DivalentHistamineHistamine H1 AntagonistsMapk1 protein, ratMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muc5ac protein, ratMucin 5ACOlopatadine Hydrochlorideconjunctival goblet cellsERK phosphorylationH1-receptor antagonist olopatadineintracellular calcium [Ca2+]i concentrationMUC5AC

Identifiers

PMID34709518
OpenAlexW3175375547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.