Evidence map›Paper›PMID 34709488›Full record

ArticleJournal of molecular histology2022

Expression and localization of amelotin, laminin γ2 and odontogenesis-associated phosphoprotein (ODAPH) on the basal lamina and junctional epithelium.

Cong Li, Yan Gao, Zhenzhen Xu, Yuan Tian, Haiyu Mu, Cuicui Yu, Yuguang Gao, Li Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Ameloblastin and its multifunctionality in amelogenesis: A review.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Cong LiInstitute of Stomatology, Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Yan GaoDepartment of Pediatrics and Preventive Dentistry, Hospital Affiliated to Binzhou Medical University, Binzhou, 256600, Shandong, China.
Zhenzhen XuDepartment of Pediatrics and Preventive Dentistry, Hospital Affiliated to Binzhou Medical University, Binzhou, 256600, Shandong, China.
Yuan TianInstitute of Stomatology, Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Haiyu MuInstitute of Stomatology, Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Cuicui YuInstitute of Stomatology, Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Yuguang GaoInstitute of Stomatology, Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China. gaoyuguang@yahoo.com.
Li ZhangInstitute of Stomatology, Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China. zhangli@bzmc.edu.cn.ORCID http://orcid.org/0000-0002-7341-1930
Binzhou Medical University · CN

Funding

National Natural Science Foundation of China 81670954National Natural Science Foundation of China 81870738Shandong medical and health technology development program 2018WS533
6 · The paper itself

Abstract

At maturation stage of enamel development, a specialized basal lamina (sBL) was built between ameloblasts and enamel. After the teeth eruption, the ameloblasts transform into the inner cell layer of junctional epithelium. The inner cell layer forms the internal basal lamina of junctional epithelium. However, the composition of the sBL and internal basal lamina was not clarified. The objective of our study was to make a description of the localization of amelotin (AMTN), laminin γ2 (LAMC2) and Odontogenesis-associated phosphoprotein (ODAPH) on the sBL and internal basal lamina. In immunohistochemical study, AMTN, LAMC2 and ODAPH were detected on the sBL at maturation stage. AMTN was also detected in ameloblasts at maturation stage. The expression of AMTN decreased from early-to-late maturation stage. In contrast, the expression of LAMC2 and ODAPH was stable. Immunofluorescence double-staining showed the localization of AMTN was close to enamel surface. However, the localization of ODAPH was close to ameloblasts. LAMC2 and ODAPH were observed on internal basal lamina of junctional epithelium. In contrast, no expression of AMTN was detected on internal basal lamina of junctional epithelium. Our results suggested that ODAPH might participate in enamel maturation and periodontal health, which might provide a better understanding of enamel defects and periodontal disease in clinic.

Indexed as

AmelogenesisAnimalsBasement MembraneDental Enamel ProteinsEpithelial AttachmentExtracellular Matrix ProteinsFluorescent Antibody Technique, IndirectLamininMiceMice, Inbred C57BLOdontogenesisPhosphoproteinsAmtn protein, mouseDental Enamel ProteinsExtracellular Matrix ProteinsLamc2 protein, mouseLamininOdaph protein, mousePhosphoproteinsAMTNBasal laminaImmunohistochemistryJunctional epitheliumLAMC2ODAPH

Identifiers

PMID34709488
OpenAlexW3208528047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.