Evidence map›Paper›PMID 34709373›Full record

ArticleAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2022

Characteristics and Outcomes of US Patients Hospitalized With COVID-19.

Ithan D Peltan, Ellen Caldwell, Andrew J Admon, Engi F Attia, Stephanie J Gundel, Kusum S Mathews, Alexander Nagrebetsky, Sarina K Sahetya, Christine Ulysse, Samuel M Brown and 15 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  9. Several laboratory variables indicate severity and prognosis of COVID-19.The Journal of international medical research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 2 countries.

Ithan D PeltanIthan D. Peltan is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Intermountain Medical Center, Murray, Utah, and an adjunct assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.
Ellen CaldwellEllen Caldwell is a data analyst/biostatistician, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle.
Andrew J AdmonAndrew J. Admon is a clinical instructor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan School of Medicine, Ann Arbor.
Engi F AttiaEngi F. Attia is an assistant professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington.
Stephanie J GundelStephanie J. Gundel is a research coordinator, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington.
Kusum S MathewsKusum S. Mathews is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine and Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Alexander NagrebetskyAlexander Nagrebetsky is an assistant professor, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Sarina K SahetyaSarina K. Sahetya is an assistant professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Christine UlysseChristine Ulysse is a statistician, Division of Biostatistics, Department of Medicine, Massachusetts General Hospital.
Samuel M BrownSamuel M. Brown is a professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Intermountain Medical Center, and Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah School of Medicine.
Steven Y ChangSteven Y. Chang is a professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine at University of California, Los Angeles (UCLA).
Andrew J GoodwinAndrew J. Goodwin is a professor, Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, Medical University of South Carolina, Charleston.
Aluko A HopeAluko A. Hope is an associate professor, Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center and Albert Einstein School of Medicine, Bronx, New York.
Theodore J IwashynaTheodore J. Iwashyna is a professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan School of Medicine, and Veterans Affairs (VA) Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan.
Nicholas J JohnsonNicholas J. Johnson is an associate professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, and Department of Emergency Medicine, University of Washington.
Michael J LanspaMichael J. Lanspa is an associate professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Intermountain Medical Center, and Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Utah School of Medicine.
Lynne D RichardsonLynne D. Richardson is a professor, Departments of Emergency Medicine and Population Health Sciences, and codirector, Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai.
Kelly C VranasKelly C. Vranas is an assistant professor, Center to Improve Veteran Involvement in Care, VA Portland Health Care System, Portland, Oregon, and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University, Portland.
Derek C AngusDerek C. Angus is a professor and chair, Department of Critical Care Medicine, University of Pittsburgh Medical Center and University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania.
Rebecca M BaronRebecca M. Baron is an associate professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston.
Benjamin A HaalandBenjamin A. Haaland is an associate professor, Department of Population Health Sciences, University of Utah School of Medicine.
Douglas L HaydenDouglas L. Hayden is an assistant professor, Division of Biostatistics, Department of Medicine, Massachusetts General Hospital.
B Taylor ThompsonB. Taylor Thompson is a professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School.
Todd W RiceTodd W. Rice is an associate professor, Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Catherine L HoughCatherine L. Hough is a professor and chief, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health and Science University.
Intermountain Medical Center · USMassachusetts General Hospital · USIcahn School of Medicine at Mount Sinai · USAlbert Einstein College of Medicine · USBrigham and Women's Hospital · USCaldwell University · USCancer Research And Biostatistics · USInstituto Benjamin Constant · BRJohns Hopkins University · USMedical University of South Carolina · USMichigan Medicine · USPulmonary and Allergy Associates · USPulmonary and Critical Care Associates · USRonald Reagan UCLA Medical Center · USSleep Research Society · USUniversity of Pittsburgh · USUniversity of Washington · USVA Center for Clinical Management Research · USVanderbilt University · USVA Portland Health Care System · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL NetworkU01HL123009 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, THOMPSON, BOYD TAYLOR · 2014 to 2021
$67.2M
Research Training for AnesthetistsT32GM007592 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI STUART A FORMAN · 1985 to 2026
$11.8M
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123022 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAPIRO, NATHAN I, TALMOR, DANIEL STUART · 2014 to 2020
$2.9M
Prevention and Early Treatment of Acute Lung InjuryU01HL123004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2014 to 2020
$2.6M
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123031 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HYZY, ROBERT C, PARK, PAULINE K · 2014 to 2020
$2.6M
Enhancing the Surrogate Informed Consent Process for Critical Care ResearchU01HL123010 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GINDE, ADIT A., MOSS, MARC · 2014 to 2020
$2.6M
Prevention and Early Treatment of Acute Lung Injury Clinical Trials NetworkU01HL123033 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICE, TODD W · 2014 to 2020
$2.4M
Preventive and Early Treatment of Acute Lung Injury Clinical Trials Network- Pgh - SupplementU01HL123020 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C, YEALY, DONALD M · 2014 to 2020
$2.4M
Long Term Outcomes and Macrophage Biology in Patients with EVALIU01HL123018 · NHLBI · IHC HEALTH SERVICES, INC. · PI BLEDSOE, JOSEPH R, BROWN, SAMUEL MORRIS · 2014 to 2020
$2.4M
Pacific Northwest Clinical Center for the NHLBI PETAL NetworkU01HL123008 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, ROBINSON, BRYCE · 2014 to 2020
$2.3M
Acute Lung Injury Group New England Program to Support PETAL Network ResearchU01HL122989 · NHLBI · BAYSTATE MEDICAL CENTER, INC. · PI STEINGRUB, JAY S · 2014 to 2020
$2.2M
HSRD VA IK2 HX003005NCRR NIH HHS UL1 RR025758NHLBI NIH HHS K08 HL155407NHLBI NIH HHS K24 HL141526NHLBI NIH HHS U01 HL122989NHLBI NIH HHS U01 HL122998NHLBI NIH HHS U01 HL123004NHLBI NIH HHS U01 HL123008NHLBI NIH HHS U01 HL123009NHLBI NIH HHS U01 HL123010NHLBI NIH HHS U01 HL123018NHLBI NIH HHS U01 HL123020NHLBI NIH HHS U01 HL123022NHLBI NIH HHS U01 HL123023NHLBI NIH HHS U01 HL123027NHLBI NIH HHS U01 HL123031NHLBI NIH HHS U01 HL123033NIGMS NIH HHS T32 GM007592
6 · The paper itself

Abstract

backgroundUnderstanding COVID-19 epidemiology is crucial to clinical care and to clinical trial design and interpretation.

objectiveTo describe characteristics, treatment, and outcomes among patients hospitalized with COVID-19 early in the pandemic.

methodsA retrospective cohort study of consecutive adult patients with laboratory-confirmed, symptomatic SARS-CoV-2 infection admitted to 57 US hospitals from March 1 to April 1, 2020.

resultsOf 1480 inpatients with COVID-19, median (IQR) age was 62.0 (49.4-72.9) years, 649 (43.9%) were female, and 822 of 1338 (61.4%) were non-White or Hispanic/Latino. Intensive care unit admission occurred in 575 patients (38.9%), mostly within 4 days of hospital presentation. Respiratory failure affected 583 patients (39.4%), including 284 (19.2%) within 24 hours of hospital presentation and 413 (27.9%) who received invasive mechanical ventilation. Median (IQR) hospital stay was 8 (5-15) days overall and 15 (9-24) days among intensive care unit patients. Hospital mortality was 17.7% (n = 262). Risk factors for hospital death identified by penalized multivariable regression included older age; male sex; comorbidity burden; symptoms-to-admission interval; hypotension; hypoxemia; and higher white blood cell count, creatinine level, respiratory rate, and heart rate. Of 1218 survivors, 221 (18.1%) required new respiratory support at discharge and 259 of 1153 (22.5%) admitted from home required new health care services.

conclusionsIn a geographically diverse early-pandemic COVID-19 cohort with complete hospital folllow-up, hospital mortality was associated with older age, comorbidity burden, and male sex. Intensive care unit admissions occurred early and were associated with protracted hospital stays. Survivors often required new health care services or respiratory support at discharge.

Indexed as

COVID-19AgedFemaleHospitalizationHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedPandemicsRespiration, ArtificialRetrospective StudiesSARS-CoV-2

Identifiers

PMID34709373
PMCPMC8891038
OpenAlexW3210957001

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.