Evidence map›Paper›PMID 34709149›Full record

ArticleBJPsych open2021

Novel insights into irritability: the relationship between subjective experience, age and mood.

Erica Bell, Gin S Malhi, Zola Mannie, Philip Boyce, Richard Bryant, Maree Inder, Richard J Porter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Erica BellAcademic Department of Psychiatry, Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; and CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, Australia.ORCID https://orcid.org/0000-0002-8483-8497
Gin S MalhiAcademic Department of Psychiatry, Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; and CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, Australia.ORCID https://orcid.org/0000-0002-4524-9091
Zola MannieAcademic Department of Psychiatry, Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, Australia; and NSW Health, Royal North Shore Hospital, Northern Sydney Local Health District, Australia.
Philip BoyceSpeciality of Psychiatry, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Australia.ORCID https://orcid.org/0000-0002-9816-7356
Richard BryantSchool of Psychology, University of New South Wales, Australia.ORCID https://orcid.org/0000-0002-9607-819X
Maree InderDepartment of Psychological Medicine, University of Otago, New Zealand.ORCID https://orcid.org/0000-0002-6326-6100
Richard J PorterDepartment of Psychological Medicine, University of Otago, New Zealand.ORCID https://orcid.org/0000-0002-8695-3966
The University of Sydney · AUUniversity of Otago · NZUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between irritability as a subjective experience and the behavioural indicators typically used to measure the construct are not known. Its links to mood, and contextual relationships, vary with age and are yet to be thoroughly examined.

aimsFirst, to interrogate the relationship between the subjective experience of irritability and mood, and that with its behavioural indicators. Second, to determine how these relationships vary with age and over time.

methodThis study examined data from a previous clinical trial of adolescents and young adults (N = 82) with bipolar disorder, who received a psychological intervention over 18 months. Participants completed a battery of questionnaires, which included assessments of irritability. Analyses of covariance were conducted to examine the interaction between mood symptoms, subjective measures of irritability, behavioural measures of irritability and age over time.

resultsSubjective irritability scores differed significantly over time when controlling for manic, but not depressive, symptom scores. Further, subjective irritability significantly differed when controlling for behavioural measures of irritability (temper outbursts and argumentativeness). There were significant interactions between scores of depressive symptoms, temper outbursts and subjective irritability with age, wherein younger participants showed no correlation between depressive symptoms and temper outbursts. In addition, younger participants showed lower correlations between subjective irritability and both depressive and temper outburst scores, than older participants.

conclusionsSubjective irritability is linked to mood morbidity and behavioural outbursts, and these relationships are contingent on age. Our novel findings suggest that subjective irritability should be assessed in greater detail in patients with mood disorders.

Indexed as

Bipolar affective disordersdepressive disordersnosologyphenomenologypsychosocial interventions

Identifiers

PMID34709149
PMCPMC8570102
OpenAlexW3209932054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.