Evidence map›Paper›PMID 34709114›Full record

ArticleBioengineered2021

Sevoflurane protects against cerebral ischemia/reperfusion injury via microrna-30c-5p modulating homeodomain-interacting protein kinase 1.

Guoning Su, Yan Qu, Gang Li, Min Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Emerging Role of MicroRNA-30c in Neurological Disorders.International journal of molecular sciences · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guoning SuDepartment of Anesthesia, Affiliated Hospital of Yunnan University, KunMing City, China.
Yan QuDepartment of Anesthesia, Affiliated Hospital of Yunnan University, KunMing City, China.
Gang LiDepartment of Anesthesia, Affiliated Hospital of Yunnan University, KunMing City, China.
Min DengDepartment of Anesthesia, Affiliated Hospital of Yunnan University, KunMing City, China.
Yunnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sevoflurane (SEV) has been reported to be an effective neuroprotective agent for cerebral ischemia/reperfusion injury (CIRI). However, the precise molecular mechanisms of Sev preconditioning in CIRI remain largely unknown. Therefore, CIRI model was established via middle cerebral artery occlusion method. SEV was applied before modeling. after successful modeling, lentivirus was injected into the lateral ventricle of the brain. Neurological impairment score was performed in each group, and histopathologic condition, infarct volume, apoptosis, inflammation, oxidative stress, microRNA (miR)-30 c-5p and homeodomain-interacting protein kinase 1 (HIPK1) were detected. Mouse hippocampal neuronal cell line HT22 cells were pretreated with SEV, and the

Indexed as

AnimalsBase SequenceBrain IschemiaCell LineDisease Models, AnimalDown-RegulationGlucoseMaleMiceMice, Inbred C57BLMicroRNAsNeuroprotective AgentsOxygenProtein Serine-Threonine KinasesRatsReperfusion InjuryGlucoseHipk1 protein, mouseMicroRNAsMirn30d microRNA, mouseNeuroprotective AgentsOxygenProtein Serine-Threonine KinasesSevofluraneCerebral ischemia-reperfusion injuryHomeodomain-interacting protein kinase 1MicroRNA-30c-5pSevoflurane

Identifiers

PMID34709114
PMCPMC8810137
OpenAlexW3210762258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.