Evidence map›Paper›PMID 34709068›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Evidence of reduced peripheral microvascular function in young Black women across the menstrual cycle.

Michele N D'Agata, Elissa K Hoopes, Felicia R Berube, Alexandra E Hirt, Andrew V Kuczmarski, Sushant M Ranadive, Megan M Wenner, Melissa A Witman

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Endocrine enigmas: vascular health in females throughout the lifespan.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
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  15. Article
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele N D'AgataDepartment of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware.
Elissa K HoopesDepartment of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, Delaware.ORCID 0000-0001-6785-7007
Felicia R BerubeDepartment of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware.
Alexandra E HirtDepartment of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware.
Andrew V KuczmarskiDepartment of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware.
Sushant M RanadiveDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.ORCID 0000-0003-1674-4285
Megan M WennerDepartment of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware.ORCID 0000-0003-0055-783X
Melissa A WitmanDepartment of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware, Newark, Delaware.ORCID 0000-0002-6166-9627

Funding

Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI SIONS, JACLYN MEGAN · 2016 to 2025
$23.3M
Cardiovascular Consequences of Duchenne and Becker Muscular DystrophinopathiesR01HL155764 · NHLBI · UNIVERSITY OF DELAWARE · PI WITMAN, MELISSA A.H. · 2021 to 2025
$3.1M
NHLBI NIH HHS R01 HL155764NIGMS NIH HHS P20 GM113125NIH HHS NIH P20 GM113125
6 · The paper itself

Abstract

Black women (BLW) have a higher prevalence of cardiovascular disease (CVD) morbidity and mortality compared with White women (WHW). A racial disparity in CVD risk has been identified early in life as young adult BLW demonstrate attenuated vascular function compared with WHW. Previous studies comparing vascular function between premenopausal WHW and BLW have been limited to the early follicular (EF) phase of the menstrual cycle, which may not reflect their vascular function during other menstrual phases. Therefore, we evaluated peripheral microvascular function in premenopausal WHW and BLW using passive leg movement (PLM) during three menstrual phases: EF, ovulation (OV), and mid-luteal (ML). We hypothesized that microvascular function would be augmented during the OV and ML phases compared with the EF phase in both groups, but would be attenuated in BLW compared with WHW at all three phases. PLM was performed on 26 apparently healthy premenopausal women not using hormonal contraceptives: 15 WHW (23 ± 3 yr), 11 BLW (24 ± 5 yr). There was a main effect of race on the overall change in leg blood flow (ΔLBF) (

Indexed as

Follicular PhaseMenstrual CycleFemaleHemodynamicsHumansLegPremenopauseYoung Adultpassive leg movementpremenopausal womenracial disparityvascular function

Identifiers

PMID34709068
PMCPMC8714980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.