Evidence map›Paper›PMID 34709067›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Hypercapnia-induced vasodilation in the cerebral circulation is reduced in older adults with sleep-disordered breathing.

R Rastogi, B J Morgan, M S Badr, S Chowdhuri

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02703220 (Pathophysiology-Guided Therapy for Sleep Apnea in the Elderly), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02703220 phase4recruitingnot on this map

Pathophysiology-Guided Therapy for Sleep Apnea in the Elderly

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2015 to 2027Enrolled100ConditionsSleep Apnea, Elderly AdultsArmsHyperoxia/oxygen, Acetazolamide, Finasteride
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Development and Validation of a Risk Prediction Model for In-Hospital Mortality in Patients With Acute Upper Gastrointestinal Bleeding.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

R RastogiMedical Service, Sleep Medicine Section, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan.
B J MorganDepartment of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
M S BadrMedical Service, Sleep Medicine Section, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan.
S ChowdhuriMedical Service, Sleep Medicine Section, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan.ORCID 0000-0002-5927-1169
Wayne State University · USUniversity of Wisconsin–Madison · US

Funding

Breathing Instability and Upper Airway Obstruction During Sleep: Effect of AgingI01CX000194 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI BADR, M.SAFWAN · 2009 to 2013
–
Pathophysiology-Guided Therapy for Sleep Apnea in the ElderlyI01CX001201 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI CHOWDHURI, SUSMITA · 2015 to 2018
–
Targeting Chemoreceptor Control of Breathing during Sleep to Mitigate Opioid-Associated Sleep Disordered BreathingI01CX001938 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI CHOWDHURI, SUSMITA · 2020 to 2025
–
Central Sleep Apnea: Physiologic Mechanisms to Inform TreatmentI01CX001944 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI M.Safwan Badr · 2020 to 2026
–
CSRD VA I01 CX000194CSRD VA I01 CX001201CSRD VA I01 CX001938CSRD VA I01 CX001944VA 1I01CX001201-01A1VA 1I01CX001938-01A0
6 · The paper itself

Abstract

The prevalence of sleep-disordered breathing (SDB) is higher in older adults compared with younger individuals. The increased propensity for ventilatory control instability in older adults may contribute to the increased prevalence of central apneas. Reductions in the cerebral vascular response to CO

Indexed as

HypercapniaSleep Apnea SyndromesAgedCarbon DioxideCerebrovascular CirculationHumansOxygen SaturationVasodilationCarbon Dioxidecerebrovascular responsivenesshypercapnic cerebral vasodilationhyperoxic hypercapniaolder adultssleep-disordered breathing

Identifiers

PMID34709067
PMCPMC8721948
OpenAlexW3209783276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.