Evidence map›Paper›PMID 34708871›Full record

ArticleChild development2022

Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years.

Samantha Plate, Lisa Yankowitz, Leslie Resorla, Meghan R Swanson, Shoba Sreenath Meera, Annette Estes, Natasha Marrus, Meredith Cola, Victoria Petrulla, Aubrey Faggen and 12 more

Open access · greenAbstract read
In one paragraph

Article in Child development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Foundations of Vocal Category Development in Autistic Infants.Journal of autism and developmental disorders · 2025
    Article
  4. Article
  5. Canonical babbling trajectories across the first year of life in autism and typical development.Autism : the international journal of research and practice · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Early predictors of language skills at 3 years of age vary based on diagnostic outcome: A baby siblings research consortium study.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  13. Article
  14. Parentese Elicits Infant Speech-Like Vocalizations in Typically Developing and Autistic Infants.Infancy : the official journal of the International Society on Infant Studies
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 3 countries.

Samantha PlateCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8812-5534
Lisa YankowitzCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Leslie ResorlaBryn Mawr College, Bryn Mawr, Pennsylvania, USA.
Meghan R SwansonUniversity of Texas at Dallas, Richardson, Texas, USA.ORCID 0000-0001-8474-3458
Shoba Sreenath MeeraNational Institute of Mental Health and Neurosciences, Bangalore, India.ORCID 0000-0001-8867-9457
Annette EstesDepartment of Speech and Hearing Sciences, University of Washington, Seattle, Washington, USA.
Natasha MarrusDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA.
Meredith ColaCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Victoria PetrullaCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Aubrey FaggenCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Juhi PandeyCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Sarah PatersonThe James S. McDonnel Foundation, Saint Louis, Missouri, USA.
John R PruettDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA.
Heather HazlettUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Stephen DagerDepartment of Speech and Hearing Sciences, University of Washington, Seattle, Washington, USA.
Tanya St JohnDepartment of Speech and Hearing Sciences, University of Washington, Seattle, Washington, USA.
Kelly BotteronDepartment of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA.
Lonnie ZwaigenbaumDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, USA.
Joseph PivenUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Robert T SchultzCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Julia Parish-MorrisCenter for Autism Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-9633-2904
IBIS Network
Children's Hospital of Philadelphia · USUniversity of Washington · USWashington University in St. Louis · USUniversity of North Carolina at Chapel Hill · USBryn Mawr College · USJames S. McDonnell Foundation · USNational Institute of Mental Health and Neurosciences · INThe University of Texas at Dallas · USUniversity of Alberta · CA

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
MRI-Based Presymptomatic Prediction of ASD, and Early Infant to School-Age Brain-Behavior Trajectories, Mechanisms, and Related OutcomesR01MH118362 · NIMH · WASHINGTON UNIVERSITY · PI John R Pruett · 2019 to 2026
$16.3M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2016 to 2020
$6.3M
Infant Vocalizations as Early Markers of Autism Spectrum DisorderR03DC017944 · NIDCD · CHILDREN'S HOSP OF PHILADELPHIA · PI PARISH-MORRIS, JULIA · 2019 to 2020
$176k
Allerton FoundationAutism Science Foundation 19-006Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD055741-14McMorris Family FoundationNICHD NIH HHS P50 HD103525NICHD NIH HHS P50 HD105354NICHD NIH HHS R01 HD055741NICHD NIH HHS U54 HD086984NIDCD NIH HHS 1R03DC017944NIDCD NIH HHS R03 DC017944NIMH NIH HHS 1R01MH118362-01NIMH NIH HHS 3R01MH118362-02S1NIMH NIH HHS R01 MH118362Simons Foundation
6 · The paper itself

Abstract

Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR-ASD infants produced fewer vocalizations than HR-Neg infants. From 6 to 24 months, HR-Neg infants demonstrated steeper vocalization growth compared to HR-ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.

Indexed as

Autism Spectrum DisorderAutistic DisorderBiomarkersCommunicationFemaleHumansInfantPhenotypeProspective StudiesSiblingsBiomarkers

Identifiers

PMID34708871
PMCPMC9112828
OpenAlexW3209975159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.