Evidence map›Paper›PMID 34708785›Full record

Trial reportIndian journal of ophthalmology2021

Effect of sustained-release long-acting intravitreal dexamethasone implant in patients of non-proliferative diabetic retinopathy undergoing phacoemulsification: A randomized controlled trial.

Parul Chawla Gupta, Jagat Ram, M Praveen Kumar, Aniruddha Agarwal, Vishali Gupta, Ramandeep Singh, Reema Bansal, Deeksha Katoch, Mangat R Dogra, Amod Gupta

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Parul Chawla GuptaDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jagat RamDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
M Praveen KumarDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Aniruddha AgarwalDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Vishali GuptaDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ramandeep SinghDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Reema BansalDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Deeksha KatochDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mangat R DograDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Amod GuptaDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Creative Commons · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCataract and diabetes, both being a major health care problem, an intervention evaluated for the combination of the two attains paramount importance. The purpose of the study was to determine the role of intraoperative intravitreal dexamethasone implant in patients with diabetic retinopathy with/without macula edema undergoing phacoemulsification.

methodsThe study was a two-arm, single-center, randomized, assessor-blinded trial of 151 patients with type-2 diabetes mellitus and cataract. It had two groups: dexamethasone group (DEX) versus standard of care (SOC) group, i.e. phacoemulsification and intraocular lens (IOL) implantation without injection of dexamethasone drug delivery system (DDS). The number of rescue interventions required, central macular thickness by optical coherence tomography (OCT), Early Treatment Diabetic Retinopathy Study (ETDRS) score, laser flare meter (LFM) values, intraocular pressure (IOP), and grade of diabetic retinopathy (DR) were recorded until three months follow up. Macular thickness and number of rescue medications between the treatment groups were the co-primary outcomes.

resultsA statistically significant interaction was present between treatment and time on OCT score (P < 0.001). The requirement of rescue interventions in the dexamethasone DDS group [40.2% (33/82)] was lesser as compared to the SOC group [49.3% (34/69)] at the end of 12 weeks [odds ratio (OR), 0.70 (0.36-1.33)] follow up although not statistically significant (P = 0.343). A statistically significant interaction was present between treatment and time on LFM score (P = 0.003). No statistically significant interaction was present between the treatment and time on visual acuity score (P = 0.08) and IOP score (P = 0.375).

conclusionDexamethasone implant may have potential as a valuable therapy for patients undergoing cataract surgery with DR with/without macular edema with effects lasting for at least three months.

Indexed as

Diabetes MellitusDiabetic RetinopathyPhacoemulsificationDelayed-Action PreparationsDexamethasoneDrug ImplantsGlucocorticoidsHumansIntravitreal InjectionsTomography, Optical CoherenceDelayed-Action PreparationsDexamethasoneDrug ImplantsGlucocorticoidsCataractdexamethasone intravitreal implantdiabetic macular edemaphacoemulsification

Identifiers

PMID34708785
PMCPMC8725102
OpenAlexW3208977284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.