Evidence map›Paper›PMID 34708772›Full record

ArticleIndian journal of ophthalmology2021

Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema.

Nibha Mishra, Malvika Singh, Rajendra K Singh, Sandeep Saxena

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The Role of Müller Cells in Diabetic Macular Edema.Investigative ophthalmology & visual science · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nibha MishraDepartment of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Malvika SinghDepartment of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Rajendra K SinghCSIR-Indian Institute of Toxicological Research, Lucknow and Department of Biochemistry, State Medical College Bahraich, Uttar Pradesh, India.
Sandeep SaxenaDepartment of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.
King George's Medical University · INIndian Institute of Toxicology Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdvanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of "metabolic memory" even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic macular edema (DME).

methodsA tertiary-care-center-based cross-sectional study included 40 consecutive cases with DME and 20 healthy controls in the age group of 40-65 years. All the study subjects underwent spectral-domain optical coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ was defined as a hyperreflective band below the external limiting membrane. The disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were assessed by assay of N

resultsSubfoveal EZ disruption was noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, visual acuity (LogMAR VA) was 0.60 ± 0.52, whereas in cases with EZ disruption, LogMAR VA was 0.96 ± 0.56 (P < 0.001). In the cases without EZ disruption, N

conclusionIn DME, increased levels of AGEs are significantly associated with EZ disruption on SD-OCT.

Indexed as

Diabetes MellitusDiabetic RetinopathyMacular EdemaAdultAgedCross-Sectional StudiesGlycation End Products, AdvancedHumansMiddle AgedProspective StudiesRetrospective StudiesTomography, Optical CoherenceGlycation End Products, AdvancedAdvanced glycation end productsdiabetic macular edemadiabetic retinopathyEZspectral-domain optical coherence tomography

Identifiers

PMID34708772
PMCPMC8725141
OpenAlexW3209734937

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.