Evidence map›Paper›PMID 34708762›Full record

ArticleIndian journal of ophthalmology2021

Identification of risk factors for targeted diabetic retinopathy screening to urgently decrease the rate of blindness in people with diabetes in India.

Sagnik Sen, Kim Ramasamy, T P Vignesh, Naresh B Kannan, Sobha Sivaprasad, Ramachandran Rajalakshmi, Rajiv Raman, Viswanathan Mohan, Taraprasad Das, Iswarya Mani

Open access · diamondAbstract read
In one paragraph

Article in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Sagnik SenDepartment of Retina and Vitreous Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Kim RamasamyDepartment of Retina and Vitreous Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
T P VigneshDepartment of Retina and Vitreous Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Naresh B KannanDepartment of Retina and Vitreous Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Sobha SivaprasadDepartment of Medical Retina, NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom.
Ramachandran RajalakshmiMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu, India.
Rajiv RamanShri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Viswanathan MohanMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu, India.
Taraprasad DasSrimati Kanuri Santhamma Centre for Vitreo Retinal Diseases, Kallam Anji Reddy Campus, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
Iswarya ManiDepartment of Biostatistics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.
Aravind Eye Hospital · INDr. Mohan's Diabetes Specialities Centre · INL V Prasad Eye Institute · INMedical Research Foundation · GBMoorfields Eye Hospital NHS Foundation Trust · GBSankara Nethralaya · IN

Funding

Medical Research Council MR/P027881/1
6 · The paper itself

Abstract

purposeThere is an exponential rise in the prevalence of diabetes mellitus (DM) in India. Ideally all people with DM should be periodically screening for diabetic retinopathy (DR) but is not practical with current infrastructure. An alternate strategy is to identify high-risk individuals with vision-threatening diabetic retinopathy (VTDR) for priority screening and treatment.

methodsWe reanalyzed four population-based studies, conducted in South India between 2001 and 2010, and reclassified individuals above 40 years into known and newly diagnosed diabetes. Multiple regression analysis was done to identify risk factors in people with known and new DM.

resultsThe prevalence of DR in 44,599 subjects aged ≥40 years was 14.8% (18.4 and 4.7% in known and new DM, respectively), and the prevalence of VTDR was 5.1%. Higher risk factors of VTDR were older age >50 years, diabetes duration >5 years, and systolic blood pressure >140 mm Hg. Targeted screening of people with diabetes using high-risk criteria obtained from this study was able to detect 93.5% of all individuals with VTDR.

conclusionIn a limited resource country like India, a high-risk group-based targeted screening of individuals with DM could be prioritized while continuing the current opportunistic screening till India adopts universal screening of all people with DM.

Indexed as

Diabetes MellitusDiabetic RetinopathyAgedBlindnessCross-Sectional StudiesHumansIndiaPrevalenceRisk FactorsDiabetic retinopathyhigh-riskrisk factorstargeted screeningvision-threatening DR

Identifiers

PMID34708762
PMCPMC8725095
OpenAlexW3208513054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.