ArticleAngewandte Chemie (International ed. in English)2022
Crossed Regio- and Enantioselective Iron-Catalyzed [4+2]-Cycloadditions of Unactivated Dienes.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Organophosphates as Versatile Substrates in Organic Synthesis.Molecules (Basel, Switzerland) · 2024Review
- Access to optically active tetrafluoroethylenated amines based on [1,3]-proton shift reaction.Beilstein journal of organic chemistry · 2024Article
- Article
- Applications of Vanadium, Niobium, and Tantalum Complexes in Organic and Inorganic Synthesis.ACS organic & inorganic Au · 2023Review
- Crossed Regio- and Enantioselective Iron-Catalyzed [4+2]-Cycloadditions of Unactivated Dienes.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
2 authors.
Funding
Abstract
The cyclohexene motif is ubiquitous in nature and specialty chemicals. A straightforward selective access to chiral cyclohexenes from unactivated dienes and dienophiles is not feasible by classical Diels-Alder reaction and constitutes an unsolved synthetic challenge. We report a mild and enantioselective iron-catalyzed cross-[4+2]-cycloaddition of unactivated dienes providing access to chiral 1,3-substituted vinyl-cyclohexenes. The development of bis-dihydroisoquinoline ligands was vital to obtain iron complexes that display high reactivities and excellent chemo-, regio- and enantioselectivities towards the targeted cyclohexenes. A range of diene substrates is well accommodated including feedstocks like butadiene, isoprene and myrcene. The structures of different iron complexes are mapped by X-ray crystallographic analysis and linked to their performance.
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