ArticleHuman brain mapping2022
Mental health in the UK Biobank: A roadmap to self-report measures and neuroimaging correlates.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Breaking the norm: population-scale deviations of brain structure in depression and anxiety.Molecular psychiatry · 2026Article
- Exposome factors predict the association between sleep health and depression.medRxiv : the preprint server for health sciences · 2026Article
- Plasma Metabolomic and Proteomic Profiling of the Mechanisms Underlying the Cumulative Impact of Co-occurring Psychiatric Disorders on Atopic Dermatitis.Acta dermato-venereologica · 2026Article
- Genetic influence on functional brain activation to an affective face matching task: an fMRI twin-study.Translational psychiatry · 2026Article
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Cross-sectional and prospective associations between multidimensional psychological distress and urogenital disorders: findings from the UK biobank.Scientific reports · 2026Article
- Article
- Multimodal fusion of brain imaging and proteomics reveals a brain-body pathway linking depression and metabolic dysfunction.Psychological medicine · 2026Article
- Joint effects of childhood adversity and genetic risk for psychosis on psychopathology in the UK Biobank.Psychological medicine · 2026Article
- Association of childhood maltreatment with DXA‑derived body composition in middle‑aged and older adults: mediating roles of unhealthy lifestyle and depression.BMC psychiatry · 2026Article
- Shared Neurocardiac Pathways Linking Atrial Fibrillation and Depression: A UK Biobank Analysis.medRxiv : the preprint server for health sciences · 2026Article
- Longitudinal associations of dynamic transitions of multidimensional health vulnerability with cardiovascular disease risk: evidence from UK Biobank.Frontiers in public health · 2026Article
- The neuroimaging correlates of depression established across six large-scale population datasets.Nature. Mental health · 2026Article
- Profiles of Aging Based on Cognition, Affect, and Brain Reserve.bioRxiv : the preprint server for biology · 2025Article
- Generating synthetic task-based brain fingerprints for population neuroscience using deep learning.Communications biology · 2025Article
- Normative amygdala fMRI response during emotional processing as a trait of depressive symptoms in the UK Biobank.Psychological medicine · 2025Article
- Parsing Clinical and Neurobiological Sources of Heterogeneity in Depression.Biological psychiatry · 2025Article
- Bidirectional associations between adiposity and mental health: a prospective cohort study of the UK Biobank.Obesity (Silver Spring, Md.) · 2025Article
- Cross-Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change.Human brain mapping · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
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Authors and funding
6 authors.
Funding
Abstract
The UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self-report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS-4) score which we recommend for state-dependent and longitudinal research in the UKB. We furthermore tested univariate and multivariate associations between brain imaging-derived phenotypes (IDPs) and mental health. Our results showed a significant multivariate relationship between IDPs and mental health, which was replicable. Conversely, effect sizes for individual IDPs were small. Test-retest reliability of IDPs was stronger for measures of brain structure than for measures of brain function. Taken together, these results provide benchmarks and guidelines for future UKB research into brain biomarkers of mental health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.