Evidence map›Paper›PMID 34708456›Full record

ReviewSeminars in dialysis

Feeling gutted in chronic kidney disease (CKD): Gastrointestinal disorders and therapies to improve gastrointestinal health in individuals CKD, including those undergoing dialysis.

Annabel Biruete, Andrea Shin, Brandon M Kistler, Sharon M Moe

Registry-linked trialAbstract readReview
In one paragraph

Review in Seminars in dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06368713 (Exercise Improves Gastrointestinal Function in Peritoneal Dialysis Patients), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06368713 naunknown statusnot on this map

Exercise Improves Gastrointestinal Function in Peritoneal Dialysis Patients: A Single Center Prospective Randomized Controlled Study

TypeinterventionalSponsorSichuan Academy of Medical SciencesRan2024 to 2025Enrolled132ConditionsPeritoneal Dialysis, Exercise, Gastrointestinal Function, Quality of LifeArmsExercise
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. International journal of molecular sciences · 2026
    Article
  5. Article
  6. Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025
    Review
  7. Article
  8. Homemade formulas for nutrition support in chronic kidney disease: A narrative review of the opportunity for education, research, and innovation.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Nutrients · 2024
    Review
  13. Article
  14. Gut Microbiota and Uremic Retention Solutes in Adults With Moderate CKD: A 6-Day Controlled Feeding Study.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2024
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Annabel BirueteDepartment of Nutrition and Dietetics, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA.ORCID 0000-0003-2549-0539
Andrea ShinDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Brandon M KistlerDepartment of Nutrition and Health Science, Ball State University, Muncie, Indiana, USA.
Sharon M MoeDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Indiana University School of MedicineBall State University · USUniversity of Indianapolis · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Resource CoreP30AR072581 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe · 2017 to 2026
$8.3M
Pathogenesis of compromised bone quality and mechanics in chronic kidney disease.R01DK110871 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ALLEN, MATTHEW R, MOE, SHARON M · 2016 to 2019
$1.8M
Indiana University Kidney Training Program (IU-KTP)T32DK120524 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M · 2019 to 2023
$1.3M
Fecal microbiota, short chain fatty acids, bile acids, and colonic transit in Irritable Bowel SyndromeK23DK122015 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI SHIN, ANDREA · 2019 to 2022
$812k
NCATS NIH HHS UL1 TR002529NIAMS NIH HHS P30 AR072581NIDDK NIH HHS K23 DK122015NIDDK NIH HHS K23DK122015NIDDK NIH HHS R01 DK110871NIDDK NIH HHS T32 DK120524
6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects 9.1% of the population worldwide. CKD may lead to structural and functional gastrointestinal alterations, including impairment in the intestinal barrier, digestion and absorption of nutrients, motility, and changes to the gut microbiome. These changes can lead to increased gastrointestinal symptoms in people with CKD, even in early grades of kidney dysfunction. Gastrointestinal symptoms have been associated with lower quality of life and reduced nutritional status. Therefore, there has been considerable interest in improving gastrointestinal health in this clinical population. Gastrointestinal health can be influenced by lifestyle and medications, particularly in advanced grades of kidney dysfunction. Therapies focused on gastrointestinal health have been studied, including the use of probiotics, prebiotics, and synbiotics, yielding limited and conflicting results. This review summarizes the alterations in the gastrointestinal tract structure and function and provides an overview of potential nutritional interventions that kidney disease professionals can provide to improve gastrointestinal health in individuals with CKD.

Indexed as

Gastrointestinal DiseasesRenal DialysisRenal Insufficiency, ChronicGastrointestinal MicrobiomeHumansProbioticsQuality of Life

Identifiers

PMID34708456
PMCPMC9043041
OpenAlexW3210656442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.