Evidence map›Paper›PMID 34708410›Full record

ArticleClinical cardiology2021

Central retinal artery occlusion as a first sign of atrial fibrillation: A 3-year retrospective single-center analysis.

Nadine Vonderlin, Karsten Kortuem, Johannes Siebermair, Martin Köhrmann, Tienush Rassaf, Steffen Massberg, Siegfried Priglinger, Stefan Kääb, Reza Wakili

Open access · goldAbstract read
In one paragraph

Article in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Central retinal artery occlusion: meta-analysis of the risk of new-onset atrial fibrillation and ischemic stroke.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  3. Review
  4. Atrial fibrillation in Retinal Artery Occlusions.Cardiology and cardiovascular medicine · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nadine VonderlinDepartment of Cardiology and Vascular Medicine, West-German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany.
Karsten KortuemEye Hospital, University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-9442-0708
Johannes SiebermairDepartment of Cardiology and Vascular Medicine, West-German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany.
Martin KöhrmannDepartment of Neurology, University of Essen Medical School, University Duisburg-Essen, Essen, Germany.
Tienush RassafDepartment of Cardiology and Vascular Medicine, West-German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany.
Steffen MassbergMedical Clinic I, University of Munich, Munich, Germany.
Siegfried PriglingerEye Hospital, University of Munich, Munich, Germany.
Stefan KääbMedical Clinic I, University of Munich, Munich, Germany.
Reza WakiliDepartment of Cardiology and Vascular Medicine, West-German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-6326-1537
München Klinik · DEUniversity of Duisburg-Essen · DEWest German Heart and Vascular Center Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral retinal artery occlusion ((C)RAO) is known to be associated with stroke and/or atrial fibrillation (AF). Nevertheless, patients often present at the ophthalmologist initially and it is unknown how many of these receive an adequate cardiological/neurological work-up (CWU/NWU), including a 24 h-Holter-ECG. HYPOTHESIS: Hypothesis of this study was that patients with (C)RAO do not undergo CWU on regular basis and that new-onset AF is more often detected in patients with CWU. METHODS AND

resultsWe performed a retrospective analysis of n = 292 consecutive patients who presented at an ophthalmology department with the diagnosis of (C)RAO during a 3-year period. After excluding patients with known AF, meeting exclusion criteria, inability to comply with the protocol, missed land phoneline, or death during follow-up a total of 174 patients were enrolled; mean follow-up was 20 ± 12 months. The CHA

conclusionOnly half of patients with (C)RAO underwent CWU. Despite minimal monitoring, rate of new diagnosed AF was high. Our results confirm that (C)RAO identifies a high-risk population for AF. These results illustrate the importance to implement standardized CWU in (C)RAO patients presenting at the ophthalmologist.

Indexed as

Atrial FibrillationRetinal Artery OcclusionStrokeAnticoagulantsHumansRetrospective StudiesRisk AssessmentRisk FactorsAnticoagulantsAFanticoagulation(C)RAOstroke

Identifiers

PMID34708410
PMCPMC8715400
OpenAlexW3210628243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.