ArticleNature reviews. Chemistry2020
Temporary or removable directing groups enable activation of unstrained C-C bonds.
Article in Nature reviews. Chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- Asymmetric radical NHC organocatalysis-enabled highly enantioselective acylation of inert C(spScience advances · 2026Article
- Catalytic C-Demethylation of Phenols and Anilines Enabled by a Removable Mono-Directing Group.Journal of the American Chemical Society · 2026Article
- Cross-ketone deacylative coupling via oxidative SNature communications · 2026Article
- A Generalized Approach for Distal C-H Arylation of Organic Building Blocks: Unveiling the Role of Counter Anion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modular esterification of unstrained carbonyls through palladium-catalyzed alkyne bridging C-C bond activation.Nature communications · 2025Article
- "Cut-and-Sew" Reactions of β-Lactams via C-C Bond Activation.Journal of the American Chemical Society · 2025Article
- Site-selective Ru-catalysed saturation of unactivated arenes via directed 6π activation.Nature catalysis · 2025Article
- Modular alkyl growth in amines via the selective insertion of alkynes into C-C bonds.Nature chemistry · 2025Article
- Deconstructive Radical-Radical Coupling for Programmable Remote Acylation.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Skeletal Rearrangements of Amides via Breaking Inert Bonds.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Skeletal Modification via Activation of Relatively Unstrained C-C Bonds.Accounts of chemical research · 2025Article
- Sandwich-Structured Fluorinated Polyimide Aerogel/Paraffin Phase-Change Composites Simultaneously Enables Gradient Thermal Protection and Electromagnetic Wave Transmission.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- π-π stacking assisted regioselectivity regulation in palladium-catalyzed cyclization reactions: a theoretical study.RSC advances · 2024Article
- Asymmetric Amination of Unstrained C(spJournal of the American Chemical Society · 2024Article
- Ligand-to-Metal Charge Transfer (LMCT) Catalysis: Harnessing Simple Cerium Catalysts for Selective Functionalization of Inert C-H and C-C Bonds.Accounts of chemical research · 2024Article
- Transforming cyclopropanes to enamides via σ-C-C bond eliminative borylation.Nature communications · 2024Article
- Ambient hydrogenation of solid aromatics enabled by a high entropy alloy nanocatalyst.Nature communications · 2024Article
- High-Valent Copper Catalysis Enables Regioselective Fluoroarylation of Gem-Difluorinated Cyclopropanes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Carbon-carbon (C-C) bonds constitute basic skeletons in most organic molecules. One can imagine that selective manipulation of C-C bonds would provide a direct approach to edit or alter molecular scaffolds but has been an ongoing challenge. Due to the kinetic inertness of C-C bonds, the common strategies of activating these bonds by transition metals rely on either the use of highly strained substrates or the assistance of a permanent directing group (DG), in which strain relief or formation of stable metallocycles becomes the driving force. To allow more common and less strained compounds utilized as substrates for C-C activation, the use of temporary and removable DGs has emerged as an attractive strategy in the past two decades. A variety of C-C bonds in unstrained or less strained organic molecules now can be converted to more reactive metal-carbon bonds, and further downstream transformations have led to diverse synthetic methods. This review highlights the development of catalytic approaches that can activate unstrained C-C bonds enabled by temporary or removable DGs. The content is mainly divided based on the nature of the DGs: temporary and removable. Applications of these methods in syntheses of natural products or bioactive molecules are also discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.