ArticleProceedings of the National Academy of Sciences of the United States of America1987
IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 261 citations in OpenAlex.
- Human Circulating Antibody-Producing B Cell as a Predictive Measure of Mucosal Immunity to Poliovirus.PloS one · 2016Trial
- Sulphasalazine inhibits human antigen-specific immune responses in vivo.Annals of the rheumatic diseases · 2007Trial
- Oral immunization of humans with Streptococcus sobrinus glucosyltransferase.Infection and immunity · 1987Trial
- Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease.Cell host & microbe · 2024Article
- Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission.Frontiers in immunology · 2022Review
- Association of Intestinal Microbial Dysbiosis With Chronic Obstructive Pulmonary Disease.Cureus · 2021Review
- Profiling of Intestinal Microbiota in Patients Infected with Respiratory Influenza A and B Viruses.Pathogens (Basel, Switzerland) · 2021Article
- Mucosal Priming with a Recombinant Influenza A Virus-Vectored Vaccine Elicits T-Cell and Antibody Responses to HIV-1 in Mice.Journal of virology · 2021Article
- Differential immune cell infiltrations between healthy periodontal and chronic periodontitis tissues.BMC oral health · 2020Article
- Defensive Driving: Directing HIV-1 Vaccine-Induced Humoral Immunity to the Mucosa with Chemokine Adjuvants.Journal of immunology research · 2018Review
- Antibody secreting B cells and plasma antibody response to rotavirus vaccination in infants from Kolkata India.Heliyon · 2018Article
- Microbiome effects on immunity, health and disease in the lung.Clinical & translational immunology · 2017Review
- The possible mechanisms of the human microbiome in allergic diseases.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Review
- The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma.Mediators of inflammation · 2017Review
- The Fecal Microbiota Profile and Bronchiolitis in Infants.Pediatrics · 2016Article
- Obesity, Asthma, and the Microbiome.Physiology (Bethesda, Md.) · 2016Review
- Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses.Open forum infectious diseases · 2015Article
- The microbiome in asthma.The Journal of allergy and clinical immunology · 2015Review
- Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma.PloS one · 2015Article
- Aggregate complexes of HIV-1 induced by multimeric antibodies.Retrovirology · 2014Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The finding that ingestion of antigens results in the selection induction of IgA antibodies in external secretions suggests that antigen sensitizes Peyer's patch lymphoid cells, which migrate to mucosal sites and generate local secretory IgA (S-IgA) antibody responses. Evidence for a common mucosal immune system in humans has been scanty because of the difficulty in demonstrating migratory behavior of Peyer's patch cells. In the present study, peripheral blood mononuclear cells (PBMC) from human volunteers who had ingested capsules containing killed Streptococcus mutans were assayed for spontaneous antibody-producing cells. Four of five volunteers exhibited circulating IgA-producing cells within 7 days and reached maximum responses by days 10-12. One IgA-deficient subject exhibited IgM responses with identical kinetics. Pokeweed-mitogen-stimulated PBMC produced anti-S. mutans antibodies predominantly of the IgA isotype. Significant S-IgA anti-S. mutans antibodies were detected in saliva and tears by day 14, and the antibodies reached maximum titers by 3 weeks. No changes in serum anti-S. mutans antibodies were noted. The IgA-deficient subject produced salivary secretory IgM antibodies. These results suggest that, after antigen ingestion, peripheral blood contains antigen-specific precursors of IgA plasma cells and that their presence precedes the appearance of S-IgA antibodies in external secretions. Therefore, these experiments provide further support for the existence of a common mucosal immune system in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.