Evidence map›Paper›PMID 34708031›Full record

ArticleFrontiers in bioengineering and biotechnology2021

3D Printed Integrated Multi-Layer Microfluidic Chips for Ultra-High Volumetric Throughput Nanoliposome Preparation.

Han Shan, Qibo Lin, Danfeng Wang, Xin Sun, Biao Quan, Xiang Chen, Zeyu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Han ShanDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Qibo LinSchool of Mechanical and Electrical Engineering, Central South University, Changsha, China.
Danfeng WangSchool of Mechanical and Electrical Engineering, Central South University, Changsha, China.
Xin SunSchool of Mechanical and Electrical Engineering, Central South University, Changsha, China.
Biao QuanSchool of Mechanical and Electrical Engineering, Central South University, Changsha, China.
Xiang ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Zeyu ChenSchool of Mechanical and Electrical Engineering, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although microfluidic approaches for liposomes preparation have been developed, fabricating microfluidic devices remains expensive and time-consuming. Also, owing to the traditional layout of microchannels, the volumetric throughput of microfluidics has been greatly limited. Herein an ultra-high volumetric throughput nanoliposome preparation method using 3D printed microfluidic chips is presented. A high-resolution projection micro stereolithography (PμSL) 3D printer is applied to produce microfluidic chips with critical dimensions of 400 µm. The microchannels of the microfluidic chip adopt a three-layer layout, achieving the total flow rate (TFR) up to 474 ml min

Indexed as

3D printinghigh volumetric throughputliposomemicrofluidicmulti-layer layout

Identifiers

PMID34708031
PMCPMC8542840

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.