Evidence map›Paper›PMID 34708019›Full record

ArticleFrontiers in public health2021

A Predictive and Preventive Model for Onset of Alzheimer's Disease.

Udit Singhania, Balakrushna Tripathy, Mohammad Kamrul Hasan, Noble C Anumbe, Dabiah Alboaneen, Fatima Rayan Awad Ahmed, Thowiba E Ahmed, Manasik M Mohamed Nour

Abstract read
In one paragraph

Article in Frontiers in public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Udit SinghaniaSchool of Computer Science and Engineering, Vellore Institute of Technology, Vellore, India.
Balakrushna TripathySchool of Information Technology and Engineering, Vellore Institute of Technology, Vellore, India.
Mohammad Kamrul HasanCenter for Cyber Security, Faculty of Information Science and Technology, Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia.
Noble C AnumbeDepartment of Mechanical Engineering, University of South Carolina, Columbia, SC, United States.
Dabiah AlboaneenComputer Science Department, College of Science and Humanities, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia.
Fatima Rayan Awad AhmedComputer Science Department, College of Computer Engineering and Science, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Thowiba E AhmedComputer Science Department, College of Science and Humanities, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia.
Manasik M Mohamed NourDepartment of Mathematics, College of Science and Humanity, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORKU24RR021382 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2008
$24.1M
STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIAP50MH071616 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2004 to 2008
$11.2M
Functional-anatomic exploration of cognitive controlR01AG021910 · NIA · WASHINGTON UNIVERSITY · PI BUCKNER, RANDY L · 2005 to 2009
$1.2M
NCRR NIH HHS U24 RR021382NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG021910NIMH NIH HHS P50 MH071616
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is a neurodegenerative irreversible brain disorder that gradually wipes out the memory, thinking skills and eventually the ability to carry out day-to-day tasks. The amount of AD patients is rapidly increasing due to several lifestyle changes that affect biological functions. Detection of AD at its early stages helps in the treatment of patients. In this paper, a predictive and preventive model that uses biomarkers such as the amyloid-beta protein is proposed to detect, predict, and prevent AD onset. A Convolution Neural Network (CNN) based model is developed to predict AD at its early stages. The results obtained proved that the proposed model outperforms the traditional Machine Learning (ML) algorithms such as Logistic Regression, Support Vector Machine, Decision Tree Classifier, and K Nearest Neighbor algorithms.

Indexed as

Alzheimer DiseaseAlgorithmsHumansMagnetic Resonance ImagingNeural Networks, ComputerSupport Vector MachineAlzheimer's diseaseconvolutional neural networksmachine learningpredictionpreventionsupport vector machine

Identifiers

PMID34708019
PMCPMC8542726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.