ArticlePeerJ2021
The correlation of WDR76 expression with survival outcomes and immune infiltrates in lung adenocarcinoma.
Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- WD repeat domain 76 predicts poor prognosis in lower grade glioma and provides an original target for immunotherapy.European journal of medical research · 2024Article
- WDR76 regulates 5-fluorouracil sensitivity in colon cancer via HRAS.Discover oncology · 2023Article
- RAGE is a potential biomarker implicated in immune infiltrates and cellular senescence in lung adenocarcinoma.Journal of clinical laboratory analysis · 2022Article
- Single-Cell RNA Sequencing Reveals the Role of Epithelial Cell Marker Genes in Predicting the Prognosis of Colorectal Cancer Patients.Disease markers · 2022Article
- Integrated transcriptomic and immunogenomic analysis unravels the immunological functions and prognostic landscape of WD repeat domain 76.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWD repeat domain 76 (WDR76) is a predicted member of the WD40-repeat-containing domain superfamily and possibly involves in various biological processes, but its function in cancers is poorly characterized. This study aimed to evaluate the role of WDR76 in the prognosis and immune infiltrates of lung adenocarcinoma (LUAD).
methodsWDR76 expressions in LUAD tissues and normal tissues were primarily compared by The Cancer Genome Atlas (TCGA) database, and were validated in cohorts from Gene Expression Omnibus (GEO) database. The associations between WDR76 expression and clinicopathologic characteristics were analyzed. Kaplan-Meier and Cox regression analyses were performed to determine the impact of WDR76 expression on survival outcomes. The protein interaction network of WDR76 was built using STRING website. TIMER and GEPIA databases were used to investigate the correlation between WDR76 expression and immune infiltrates.
resultsWDR76 expression was elevated in LUAD (
conclusionWDR76 expression was involved in the regulation of immune infiltrates and had predictive value for prognosis in LUAD.
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