Evidence map›Paper›PMID 34707783›Full record

ArticleOxidative medicine and cellular longevity2021

Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against Intervertebral Disc Degeneration.

Zeng Xu, Jiancheng Zheng, Ying Zhang, Huiqiao Wu, Bin Sun, Ke Zhang, Jianxi Wang, Fazhi Zang, Xingkai Zhang, Lei Guo and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zeng XuDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Jiancheng ZhengShanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.
Ying ZhangDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Huiqiao WuDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Bin SunDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Ke ZhangDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Jianxi WangDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Fazhi ZangDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.
Xingkai ZhangShanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.ORCID https://orcid.org/0000-0002-0621-2499
Lei GuoShanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.ORCID https://orcid.org/0000-0001-5143-3234
Xiaodong WuDepartment of Orthopedics, Changzheng Hospital, The Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0003-3792-2482
Second Military Medical University · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The destruction of the low oxygen microenvironment in nucleus pulposus (NP) cells played a critical role in the pathogenesis of intervertebral disc degeneration (IVDD). The purpose of this study was to determine the potential role of integrin alpha 6 (ITG

Indexed as

AdolescentAdultAnimalsApoptosisCell HypoxiaCells, CulturedDisease Models, AnimalFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitIntegrin alpha6Intervertebral Disc DegenerationMaleNucleus PulposusOxygenPhosphatidylinositol 3-KinaseHIF1A protein, humanHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitIntegrin alpha6ITGA6 protein, humanItga6 protein, ratOxygenPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-akt

Identifiers

PMID34707783
PMCPMC8545551
OpenAlexW3205436888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.