Evidence map›Paper›PMID 34707776›Full record

ReviewOxidative medicine and cellular longevity2021

Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy.

Javad Sharifi-Rad, Cristina Quispe, Jayanta Kumar Patra, Yengkhom Disco Singh, Manasa Kumar Panda, Gitishree Das, Charles Oluwaseun Adetunji, Olugbenga Samuel Michael, Oksana Sytar, Letizia Polito and 14 more

Abstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Disulfide-Crosslinked mPEG-PLA-(LA)Molecules (Basel, Switzerland) · 2026
    Article
  11. Supercritical COPharmaceutics · 2026
    Article
  12. Review
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  14. Epigenetic Reactivation of <italic>SOCS-3</italic> and Inhibition of ERK1/2 Underlie Thymoquinone-Induced Apoptosis in a Chronic Myeloid Leukemia Xenograft Model.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article
  15. Cancer: A bioelectric disease?Clinical and translational medicine · 2026
    Review
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Javad Sharifi-RadPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-7301-8151
Cristina QuispeFacultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.
Jayanta Kumar PatraResearch Institute of Biotechnology & Medical Converged Science, Dongguk University, Goyangsi, Republic of Korea.
Yengkhom Disco SinghDepartment of Post-Harvest Technology, College of Horticulture and Forestry, Central Agricultural University, Pasighat, 791102 Arunachal Pradesh, India.
Manasa Kumar PandaEnvironment and Sustainability Department, CSIR-Institute of Minerals and Materials Technology, Bhubaneswar, 751013 Odisha, India.
Gitishree DasResearch Institute of Biotechnology & Medical Converged Science, Dongguk University, Goyangsi, Republic of Korea.
Charles Oluwaseun AdetunjiApplied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo University Iyamho, PMB 04, Auchi, Edo State, Nigeria.
Olugbenga Samuel MichaelCardiometabolic Research Unit, Department of Physiology, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria.
Oksana SytarDepartment of Plant Biology Department, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 01033, Ukraine.
Letizia PolitoDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.ORCID https://orcid.org/0000-0001-8051-4981
Jelena ŽivkovićInstitute for Medicinal Plants Research "Dr. Josif Pančić", Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
Natália Cruz-MartinsFaculty of Medicine, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-5934-5201
Marta Klimek-SzczykutowiczChair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Medyczna 9, 30-688 Kraków, Poland.
Halina EkiertChair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Medyczna 9, 30-688 Kraków, Poland.
Muhammad Iqbal ChoudharyH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Seyed Abdulmajid AyatollahiPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-2018-2406
Bekzat TynybekovDepartment of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan.
Farzad KobarfardPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ana Covilca MunteanBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Timisoara, Romania.ORCID https://orcid.org/0000-0001-9867-8394
Ioana GrozeaBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Timisoara, Romania.ORCID https://orcid.org/0000-0002-2186-4364
Sevgi Durna DaştanDepartment of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Turkey.
Monica ButnariuBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Timisoara, Romania.ORCID https://orcid.org/0000-0002-2032-5000
Agnieszka SzopaChair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Medyczna 9, 30-688 Kraków, Poland.ORCID https://orcid.org/0000-0002-6351-4047
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID https://orcid.org/0000-0002-1523-9116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree

Indexed as

Medical OncologyNanomedicineAnimalsAntineoplastic Agents, PhytogenicAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsDrug CompoundingDrug SynergismFemaleHumansNanoparticlesPaclitaxelAntineoplastic Agents, PhytogenicPaclitaxel

Identifiers

PMID34707776
PMCPMC8545549

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.