Evidence map›Paper›PMID 34707701›Full record

ArticleExperimental and therapeutic medicine2021

Adipose-derived mesenchymal stem cell exosomes inhibit transforming growth factor-β1-induced collagen synthesis in oral mucosal fibroblasts.

Junjie Liu, Fuxingzi Li, Binjie Liu, Zhigang Yao, Long Li, Gui Liu, Lei Peng, Yuxin Wang, Junhui Huang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Junjie LiuHunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Fuxingzi LiDepartment of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Binjie LiuHunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Zhigang YaoHunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Long LiHunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Gui LiuHunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Lei PengDepartment of Urban Palliative Home Care, Grey Nuns Community Hospital, Edmonton, AB T5J3E4, Canada.
Yuxin WangDepartment of Stomatology, Changsha Central Hospital, Changsha, Hunan 410018, P.R. China.
Junhui HuangHunan Key Laboratory of Oral Health Research, Hunan Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410000, P.R. China.
Central South University · CNChangsha Central Hospital · CNGrey Nuns Community Hospital · CASecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral submucosal fibrosis (OSF) is a potentially malignant oral disorder that requires the further development of advanced treatment strategies. TGF-β1 has been reported to be the main trigger for the increased collagen production and reduced activity of matrix degradation pathways in OSF. Exosomes are key mediators of paracrine signaling that have been proposed for direct use as therapeutic agents for tissue repair and regeneration. The present study aimed to investigate the effects of human adipose-derived mesenchymal stem cell (ADSC) exosomes (ADSC-Exos) on TGF-β1-treated oral fibroblasts

Indexed as

adipose-derived mesenchymal stem cell exosomescollagen synthesisfibroblastsoral submucous fibrosisTGF-β1

Identifiers

PMID34707701
PMCPMC8543178
OpenAlexW3205028854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.