Evidence map›Paper›PMID 34707605›Full record

ArticleFrontiers in immunology2021

Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck.

Xiang Zhao, Liang-Zhe Wu, Esther K Y Ng, Kerisa W S Leow, Qianru Wei, Nicholas R J Gascoigne, Joanna Brzostek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiang ZhaoImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Liang-Zhe WuImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Esther K Y NgImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Kerisa W S LeowDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Qianru WeiImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Nicholas R J GascoigneImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Joanna BrzostekImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
National University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Under physiological conditions, CD8

Indexed as

AnimalsAntigen-Presenting CellsCD8-Positive T-LymphocytesCytokinesGene Expression RegulationHistocompatibility Antigens Class IHost-Pathogen InteractionsImmunological SynapsesLymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)MicePhosphorylationProtein BindingProtein TransportQuorum SensingTranscription FactorsCytokinesHistocompatibility Antigens Class ILymphocyte Specific Protein Tyrosine Kinase p56(lck)Transcription FactorsAKT pathwayco-agonismLcknon-stimulatory peptide MHCT cell effector functionsT cell receptorT cell signaling

Identifiers

PMID34707605
PMCPMC8542885
OpenAlexW3205892808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.