Evidence map›Paper›PMID 34707600›Full record

ArticleFrontiers in immunology2021

Rapid Identification of the Tumor-Specific Reactive TIL Repertoire

Arianna Draghi, Christopher Aled Chamberlain, Shawez Khan, Krisztian Papp, Martin Lauss, Samuele Soraggi, Haja Dominike Radic, Mario Presti, Katja Harbst, Aishwarya Gokuldass and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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  16. What do cancer-specific T cells 'see'?Discovery immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Arianna DraghiNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Christopher Aled ChamberlainNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Shawez KhanNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Krisztian PappDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary.
Martin LaussDivision of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Samuele SoraggiBioinformatics Research Center, Aarhus University, Aarhus, Denmark.
Haja Dominike RadicNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Mario PrestiNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Katja HarbstDivision of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Aishwarya GokuldassNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Anders KvernelandNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Morten NielsenNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Marie Christine Wulff WestergaardNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Mads Hald AndersenNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Istvan CsabaiDepartment of Physics of Complex Systems, ELTE Eötvös Loránd University, Budapest, Hungary.
Göran JönssonDivision of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Zoltan SzallasiDanish Cancer Society Research Center, Copenhagen, Denmark.
Inge Marie SvaneNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Marco DoniaNational Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.
Copenhagen University Hospital · DKLund University · SEEötvös Loránd University · HUAarhus University · DKDanish Cancer Society · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detecting the entire repertoire of tumor-specific reactive tumor-infiltrating lymphocytes (TILs) is essential for investigating their immunological functions in the tumor microenvironment. Current

Indexed as

Antigens, CDAntigens, NeoplasmApyraseCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDatasets as TopicFlow CytometryHumansIntegrin alpha ChainsInterferon-gammaLymphocyte ActivationLymphocytes, Tumor-InfiltratingNeoplasm ProteinsSingle-Cell AnalysisTranscriptomeTumor Microenvironmentalpha E integrinsAntigens, CDAntigens, NeoplasmApyraseENTPD1 protein, humanIFNG protein, humanIntegrin alpha ChainsInterferon-gammaNeoplasm ProteinsTNFRSF9 protein, humanTumor Necrosis Factor-alphaTumor Necrosis Factor Receptor Superfamily, Member 9CD137 (4-1BB)immune-monitoringimmune-responses to cancersingle-cell technologiestumor-infiltrating lymphocytes (TILs)tumor-specific activationtumor-specific reactivity

Identifiers

PMID34707600
PMCPMC8543011
OpenAlexW3206551239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.