ArticleProceedings of the National Academy of Sciences of the United States of America1987
Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 252 citations in OpenAlex.
- Article
- Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis.Nature communications · 2025Article
- CaMicroorganisms · 2022Article
- Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly.Cell reports · 2021Article
- Functional implications of CaMKII alternative splicing.The European journal of neuroscience · 2021Review
- The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders.International journal of molecular sciences · 2021Review
- Proteins with calmodulin-like domains: structures and functional roles.Cellular and molecular life sciences : CMLS · 2019Review
- A Designed Enzyme Promotes Selective Post-translational Acylation.Chembiochem : a European journal of chemical biology · 2018Article
- Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation.Scientific reports · 2018Article
- Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.The Biochemical journal · 2002Review
- Serine/threonine phosphorylation of calmodulin modulates its interaction with the binding domains of target enzymes.The Biochemical journal · 1999Article
- Structure and dynamics of calmodulin in solution.Biophysical journal · 1998Article
- Cell- and lamina-specific expression and activity-dependent regulation of type II calcium/calmodulin-dependent protein kinase isoforms in monkey visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Review
- Stimulus-dependent, reciprocal up- and downregulation of glutamic acid decarboxylase and Ca2+/calmodulin-dependent protein kinase II gene expression in rat cerebral cortex.Experimental brain research · 1996Article
- A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed.The EMBO journal · 1996Article
- An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle.Molecular and cellular biology · 1996Article
- Cell- and tissue-specific expression of putative protein kinase mRNAs in the embryonic leech, Hirudo medicinalis.Cell and tissue research · 1995Article
- Protein phosphorylation and beta-cell function.Diabetologia · 1994Review
- Two genes that encode Ca(2+)-dependent protein kinases are induced by drought and high-salt stresses in Arabidopsis thaliana.Molecular & general genetics : MGG · 1994Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
cDNA clones coding for the beta subunit of rat brain type II Ca2+/calmodulin-dependent protein kinase were isolated and sequenced. The clones, including one containing the entire coding region, hybridize at high stringency to a single band of poly(A)+ RNA of length 4.8 kilobases. The subunit coded for by the clones was identified by in vitro transcription of the cDNA followed by translation of the resulting RNA. The DNA sequence of the clones contains a single long open reading frame (1626 nucleotides) coding for a protein of 542 amino acids with a molecular weight of 60,333, the amino-terminal half of which is homologous to several other protein kinases. Potential ATP- and calmodulin-binding domains were identified. Two independent clones contain an identical 45-nucleotide deletion, relative to the clones described above, resulting in a shorter open reading frame coding for a protein of molecular weight 58,000. This suggests that the minor, 58-kDa beta' subunit of the type II Ca2+/calmodulin-dependent kinase may be synthesized on a separate message.
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