Evidence map›Paper›PMID 34707570›Full record

ArticleFrontiers in endocrinology2021

Hepatic Steatosis Contributes to the Development of Muscle Atrophy

Kenneth Pasmans, Michiel E Adriaens, Peter Olinga, Ramon Langen, Sander S Rensen, Frank G Schaap, Steven W M Olde Damink, Florian Caiment, Luc J C van Loon, Ellen E Blaak and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Kenneth PasmansDepartment of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Michiel E AdriaensMaastricht Centre for Systems Biology, Maastricht University, Maastricht, Netherlands.
Peter OlingaDepartment of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
Ramon LangenDepartment of Respiratory Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Sander S RensenDepartment of Surgery, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Frank G SchaapDepartment of Surgery, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Steven W M Olde DaminkDepartment of Surgery, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Florian CaimentDepartment of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, Netherlands.
Luc J C van LoonDepartment of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Ellen E BlaakDepartment of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Ruth C R MeexDepartment of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Maastricht University · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with hepatic steatosis often display several metabolic abnormalities including insulin resistance and muscle atrophy. Previously, we found that hepatic steatosis results in an altered hepatokine secretion profile, thereby inducing skeletal muscle insulin resistance

Indexed as

AnimalsCell CommunicationCells, CulturedCoculture TechniquesLipid MetabolismLiverMaleMiceMice, Inbred C57BLMuscle, SkeletalMuscular AtrophyNon-alcoholic Fatty Liver DiseaseSignal Transductionhepatic steatosisinsulin resistance, metabolisminter-organ crosstalkmuscle atrophyNAFLDsarcopenia

Identifiers

PMID34707570
PMCPMC8542925
OpenAlexW3206961863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.