Evidence map›Paper›PMID 34707474›Full record

ArticleFrontiers in neuroscience2021

Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging.

Jinwoo Hong, Hyuk Jin Yun, Gilsoon Park, Seonggyu Kim, Yangming Ou, Lana Vasung, Caitlin K Rollins, Cynthia M Ortinau, Emiko Takeoka, Shizuko Akiyama and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  5. Deep learning assessment of fetal brain maturation on 3D ultrasound volumes in early-onset fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Jinwoo HongDepartment of Electronic Engineering, Hanyang University, Seoul, South Korea.
Hyuk Jin YunFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Gilsoon ParkUSC Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States.
Seonggyu KimDepartment of Electronic Engineering, Hanyang University, Seoul, South Korea.
Yangming OuFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Lana VasungFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Caitlin K RollinsDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Cynthia M OrtinauDepartment of Pediatrics, Washington University in St. Louis, St. Louis, MO, United States.
Emiko TakeokaMother Infant Research Institute, Tufts Medical Center, Boston, MA, United States.
Shizuko AkiyamaCenter for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Tomo TaruiMother Infant Research Institute, Tufts Medical Center, Boston, MA, United States.
Judy A EstroffDepartment of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Patricia Ellen GrantFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Jong-Min LeeDepartment of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Kiho ImFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.
Harvard University · USHanyang University · KRBoston Children's Hospital · USTufts Medical Center · USTohoku University Hospital · JPUniversity of Southern California · USWashington University in St. Louis · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart DiseaseR01NS114087 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2020 to 2024
$2.8M
Prenatal diagnosis of brain malformations: Improving assessment of prognosisK23HD079605 · NICHD · TUFTS MEDICAL CENTER · PI TARUI, TOMO · 2015 to 2019
$767k
Physiologic and Genetic Contributions of Impaired Fetal Brain Development in Congenital Heart DiseaseK23HL141602 · NHLBI · WASHINGTON UNIVERSITY · PI ORTINAU, CYNTHIA MARIE · 2019 to 2022
$727k
NHLBI NIH HHS K23 HL141602NICHD NIH HHS K23 HD079605NICHD NIH HHS P50 HD105351NINDS NIH HHS R01 NS114087
6 · The paper itself

Abstract

The accurate prediction of fetal brain age using magnetic resonance imaging (MRI) may contribute to the identification of brain abnormalities and the risk of adverse developmental outcomes. This study aimed to propose a method for predicting fetal brain age using MRIs from 220 healthy fetuses between 15.9 and 38.7 weeks of gestational age (GA). We built a 2D single-channel convolutional neural network (CNN) with multiplanar MRI slices in different orthogonal planes without correction for interslice motion. In each fetus, multiple age predictions from different slices were generated, and the brain age was obtained using the mode that determined the most frequent value among the multiple predictions from the 2D single-channel CNN. We obtained a mean absolute error (MAE) of 0.125 weeks (0.875 days) between the GA and brain age across the fetuses. The use of multiplanar slices achieved significantly lower prediction error and its variance than the use of a single slice and a single MRI stack. Our 2D single-channel CNN with multiplanar slices yielded a significantly lower stack-wise MAE (0.304 weeks) than the 2D multi-channel (MAE = 0.979,

Indexed as

age predictionbrain agedeep learningfetal brainfetal MRI

Identifiers

PMID34707474
PMCPMC8542770
OpenAlexW3205483298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.