Evidence map›Paper›PMID 34707401›Full record

ArticleJournal of pain research2021

Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura.

Yadi Zhu, Lingling Dai, Hongru Zhao, Boan Ji, Yang Yu, Hui Dai, Chunhong Hu, Ximing Wang, Jun Ke

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In one paragraph

Article in Journal of pain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  15. The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yadi Zhu *Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Lingling Dai *Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Hongru Zhao *Department of Neurology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Boan JiMedical School of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Yang YuDepartment of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.ORCID 0000-0001-5024-559X
Chunhong HuDepartment of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Ximing WangDepartment of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.
Jun KeDepartment of Radiology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu Province, People's Republic of China.ORCID 0000-0001-5628-7870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeuroimaging studies on migraine have revealed structural and functional alterations in the hippocampus, a region involved in pain processing and stress response. This study was designed to investigate whether effective connectivity of this region is disrupted in migraine and relates to chronicity of this disease. PATIENTS AND

methodsIn 39 episodic migraine (EM) patients, 17 chronic migraine (CM) patients, and 35 healthy controls, we investigated differences in the directional influences between the hippocampus and the rest of the brain by combining resting-state functional magnetic resonance imaging and Granger causality analysis (GCA), with bilateral hippocampus as seed regions. The associations between directional influences and the clinical variables were also examined.

resultsComparing each patient group to the control group, we found increased and decreased negative influence on the hippocampus exerted by the bilateral visual areas and right dorsolateral prefrontal cortex (dlPFC), respectively. The hippocampus showed increased positive influence on the right posterior insula and medial prefrontal cortex (mPFC), as well as increased negative influence on the left cerebellum in CM patients relative to EM patients and healthy controls. Furthermore, across all patients, the migraine frequency exhibited a positive and negative association with causal influence from the hippocampus to mPFC and left cerebellum, respectively.

conclusionMigraine patients have abnormal effective connectivity between the hippocampus and multiple brain regions involved in the sensory and cognitive processing of pain. Disrupted directional influences to the hippocampus exerted by dlPFC and bilateral visual areas were common features of EM and CM patients. Directional influences from the hippocampus to mPFC and left cerebellum may be useful imaging biomarkers for assessing migraine frequency.

Indexed as

effective connectivityfunctional magnetic resonance imaginghippocampusmigraineresting-state

Identifiers

PMID34707401
PMCPMC8544273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.