Evidence map›Paper›PMID 34707385›Full record

ArticlePharmacogenomics and personalized medicine2021

Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke.

Gohar Tsakanova, Ani Stepanyan, Rudi Steffensen, Armine Soghoyan, Jens Christian Jensenius, Arsen Arakelyan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Gohar TsakanovaInstitute of Molecular Biology NAS RA, Yerevan, Armenia.ORCID 0000-0003-2072-6397
Ani StepanyanInstitute of Molecular Biology NAS RA, Yerevan, Armenia.
Rudi SteffensenDepartment of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
Armine Soghoyan"Surb Grigor Lusavorich" Medical Center CJSC, Yerevan, Armenia.
Jens Christian JenseniusDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Arsen ArakelyanInstitute of Molecular Biology NAS RA, Yerevan, Armenia.
Institute of Molecular Biology · AMAalborg University Hospital · DKA. Alikhanyan National Laboratory · AMAarhus University · DKPsychiatric Medical Center · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe current study aimed to investigate in an Armenian population the levels of pattern recognition molecules (PRMs) of lectin complement pathway (LCP), MBL (mannan-binding lectin) and M-ficolin in plasma in ischemic stroke (IS), and the possible association of 11 single nucleotide polymorphisms (SNPs) in PATIENTS AND

methodsA total of 122 patients with IS and 150 control subjects were included in this study. Immunofluorometric assays (TRIFMAs) and real-time polymerase chain reactions with

resultsAccording to the results, the levels of M-ficolin in IS patients are significantly higher than in control subjects, and the

conclusionIn conclusion, we suggest that LCP PRMs are associated with the risk of developing IS, and may also participate in pathological events leading to post-ischemic brain damage. This study emphasizes the important contribution of alterations of LCP PRMs on genomic and proteomic levels to the pathomechanisms of ischemic stroke, at least in an Armenian population.

Indexed as

haplotypeshuman ischemic strokehumoral pattern recognition moleculeslectin complement pathwaysingle nucleotide polymorphisms

Identifiers

PMID34707385
PMCPMC8544564
OpenAlexW3206869463

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.