ArticleNature2021
A synthetic antibiotic class overcoming bacterial multidrug resistance.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 226 citations in OpenAlex.
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- Deep-learning-based virtual screening of antibacterial compounds.Nature biotechnology · 2026Article
- Natural Product-Derived Ianthelliformisamines Inhibit Protein Translation and Block Bacterial Flagellum Assembly.ACS chemical biology · 2026Article
- Benzoxaborole-modified azithromycins inhibit translation without inducingAntimicrobial agents and chemotherapy · 2026Article
- Breaking resistance: strategies for novel antibacterial therapeutic interventions.Molecular biology reports · 2026Review
- Copper Single-Atoms Loaded on Molybdenum Disulphide Drive Bacterial Cuproptosis-Like Death and Interrupt Drug-Resistance Compensation Pathways.Nano-micro letters · 2026Article
- Scaffold Simplification Yields Potent Antibacterial Agents That Target Bacterial Topoisomerases.Molecules (Basel, Switzerland) · 2026Article
- Genome mining strategies to unlock the metabolic potential ofFrontiers in microbiology · 2026Article
- Biosynthesis of HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Hybrid Antibiotics Targeting the Bacterial Ribosome.ACS central science · 2025Article
- Integrated Machine Learning and Structure-Based Virtual Screening Identifies Natural Product Targeting 50S Ribosome Inhibitory Activity AgainstMolecules (Basel, Switzerland) · 2025Article
- Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria.Nature communications · 2025Article
- Antibacterial Activity of Chalcone (2E)-3-({4-[(2E)-3-(4-Nitrophenyl) prop-2-enol] phenyl}carbamoyl) prop-2-enoic acid and Its Effect Against Staphylococcus aureus Carrying Efflux Pump and β-Lactamase.Current microbiology · 2025Article
- De Novo Design and Asymmetric Synthesis of aOrganic letters · 2025Article
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- Synthesis of N-doped Carbon Quantum Dots as an Effective Fluorescent Sensor of FeJournal of fluorescence · 2025Article
- Global health perspectives on antibacterial drug discovery and the preclinical pipeline.Nature reviews. Microbiology · 2025Review
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- Anti-bacterial activity of dermcidin in human platelets: suppression of methicillin-resistantMicrobiology spectrum · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Matthew J Mitcheltree *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3774-628X
Amarnath Pisipati *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Egor A Syroegin *Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2753-3950
Katherine J SilvestreDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Dorota KlepackiDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Jeremy D MasonDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1039-0773
Daniel W TerwilligerDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Giambattista TestolinDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0080-0692
Aditya R PoteDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8703-5190
Kelvin J Y WuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Richard Porter LadleyDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3902-8292
Kelly ChatmanHarvard Center for Mass Spectrometry, Harvard University, Cambridge, MA, USA.
Alexander S MankinDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3301-827X
Yury S PolikanovDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA. yuryp@uic.edu.ORCID http://orcid.org/0000-0002-5064-0327
Andrew G MyersDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. myers@chemistry.harvard.edu.ORCID http://orcid.org/0000-0001-9602-6915
Harvard University · USUniversity of Illinois Chicago · US
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MUnraveling context specificity of translation by elucidating the mechanism of action of auxiliary translation factorsR35GM127134 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALEXANDER S MANKIN · 2018 to 2026
$3.2MPixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0MMolecular mechanisms of action of ribosome-targeting antibiotics.R01GM132302 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2019 to 2022
$1.3MStructural basis of Erm-mediated macrolide resistanceR21AI137584 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MANKIN, ALEXANDER S, POLIKANOV, YURY · 2018 to 2019
$440kNIAID NIH HHS R21 AI137584NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM132302NIGMS NIH HHS R35 GM127134NIH HHS S10 OD021527
Abstract
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern
Indexed as
Anti-Bacterial AgentsClindamycinDrug DiscoveryDrug Resistance, Multiple, BacterialLincomycinLincosamidesMethyltransferasesMicrobial Sensitivity TestsModels, MolecularOxepinsPyransRibosomesRNA, MessengerRNA, TransferThermus thermophilusAnti-Bacterial AgentsClindamyciniboxamycinLincomycinLincosamidesMethyltransferasesOxepinsPyransRNA, MessengerRNA, TransferrRNA (adenosine-O-2'-)methyltransferase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.