ArticleNature2021
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
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Who cites it
45 citing papers in PubMed, 75 citations in OpenAlex.
- TRPA1 deficiency alters brown adipose tissue proteome and thermogenic gene expression during cold exposure in mice.Biochemistry and biophysics reports · 2026Article
- IMPA2 ameliorates high-fat diet-induced obesity by enhancing adaptive thermogenesis in a Ca²⁺-activated mitochondrial biogenesis pathway.Journal of translational medicine · 2026Article
- Glycogen drives the sensory activation of POMC neurons.Nature metabolism · 2026Article
- Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Glycogen and lactate metabolism in mouse fetal Sertoli cells sustain the germ line.Cell reports · 2026Article
- PTG-Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PMAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Glycogen synthase 1 promotes breast cancer progression by promoting IκBα ubiquitination and degradation independent of its canonical enzyme function.Cell communication and signaling : CCS · 2026Article
- Cuproptosis promotes inflammatory osteolysis via GYS1-mediated glycogen metabolism.International journal of oral science · 2026Article
- Significance of neuroendocrine systems and the gut-brain axis (GBA) in the regulation of obesity.PeerJ · 2026Review
- Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health.International journal of biological sciences · 2026Review
- Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice.Nature communications · 2025Article
- Intermittent fasting and exercise: a dual intervention for orchestrating glycolipid conversion and utilization in healthy mice.Molecular and cellular biochemistry · 2025Article
- Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse Photothermal Resistance in Triple-Negative Breast Cancer.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Glycogen metabolism: not just a one-trick pony.Nature reviews. Endocrinology · 2025Article
- Untargeted metabolomics analysis reveals comparative meat quality of different muscles and the impact of Saline-alkali land feeding on Dolang sheep (Ovis aries).BMC genomics · 2025Article
- GLP-1 and Its Role in Glycogen Production: A Narrative Review.Biomedicines · 2025Review
- The genome of giant waterlily provides insights into the origin of angiosperms, leaf gigantism, and stamen function innovation.Plant communications · 2025Article
- Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice.The Journal of clinical investigation · 2025Article
- Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sustainable Utilization of Coffee Pulp, a By-Product of Coffee Production: Effects on Metabolic Syndrome in Fructose-Fed Rats.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 4 countries.
Omer KeinanDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Joseph M ValentineDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Haopeng XiaoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4166-647X
Sushil K MahataVA San Diego Healthcare System and University of California San Diego, San Diego, CA, USA.
Shannon M ReillyDepartment of Medicine, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-0412-2446
Mohammad Abu-OdehDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Julia H DelucaDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Benyamin DadpeyDepartment of Medicine, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-6253-7167
Leslie ChoDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Austin PanDepartment of Medicine, University of California San Diego, San Diego, CA, USA.
Ruth T YuGene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9527-9627
Yang DaiGene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, CA, USA.
Christopher LiddleStorr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3936-6790
Michael DownesGene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, CA, USA.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Sciences, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9986-5965
Aldons J LusisDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9013-0228
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3394-7749
Edward T ChouchaniDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9776-8790
Mikael RydénDepartment of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Stockholm, 86, Sweden.ORCID http://orcid.org/0000-0003-4785-1876
Alan R SaltielDepartment of Medicine, University of California San Diego, San Diego, CA, USA. asaltiel@health.ucsd.edu.ORCID http://orcid.org/0000-0002-9726-9828
University of California San Diego · USSalk Institute for Biological Studies · USHarvard University · USKarolinska University Hospital · SEThe University of Sydney · AUUC San Diego Health System · USUniversity of California, Los Angeles · USUniversity of Eastern Finland · FI
Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MThe Role of the Exocyst Complex in Insulin Regulated Glucose TransportR01DK076906 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SALTIEL, ALAN R. · 2007 to 2019
$4.6MEXPERIMENTAL ENDOCRINOLOGY AND METABOLISMT32DK007044 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Amit Majithia · 1986 to 2026
$4.6MSystems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6MDetermining mechanisms of the succinate thermogenesis pathways on UCP1-dependent and UCP1-independent thermogenesisR01DK123095 · NIDDK · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2019 to 2026
$4.2MRegulation of Glycogen in Health and DiseaseR01DK117551 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALAN R. SALTIEL · 2018 to 2026
$3.8MEngineering human islet-like organoids for transplantationR01DK120480 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2018 to 2021
$3.4MSystems genetics approach to inflammatory mechanisms in atherosclerosisR01HL147883 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2019 to 2022
$3.0MHormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6MInflammation and hepatic lipid metabolismR01DK125820 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALTIEL, ALAN R. · 2020 to 2023
$2.1MNCI NIH HHS P30 CA014195NHLBI NIH HHS R01 HL147883NIDDK NIH HHS F32 DK124947NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R01 DK076906NIDDK NIH HHS R01 DK117551NIDDK NIH HHS R01 DK117850NIDDK NIH HHS R01 DK120480NIDDK NIH HHS R01 DK123095NIDDK NIH HHS R01 DK125820NIDDK NIH HHS R01 DK126944NIDDK NIH HHS R37 DK057978NIDDK NIH HHS T32 DK007044NIH HHS 1R01 DK117850NIH HHS 1R01 HL147883
Abstract
Adipocytes increase energy expenditure in response to prolonged sympathetic activation via persistent expression of uncoupling protein 1 (UCP1)
Indexed as
HomeostasisThermogenesisAdaptation, PhysiologicalAdipocytesAdipocytes, BeigeAnimalsCold TemperatureEnergy MetabolismFemaleGlucoseGlycogenHumansIntracellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutGlucoseGlycogenIntracellular Signaling Peptides and Proteinsp38 Mitogen-Activated Protein KinasesPpp1r3c protein, mouseUcp1 protein, mouseUncoupling Protein 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.