ArticleNature2021
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers.
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161citing papers in PubMed
18.8field-weighted citation impact, top 1% of its field
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161 citing papers in PubMed, 236 citations in OpenAlex.
- Research progress of pancreatic cancer based on ferroptosis-cuproptosis interaction (Review).Oncology letters · 2026Review
- A high-confidence inventory of the proteins in the mitochondrion-related organelle of Giardia.Current biology : CB · 2026Article
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Cysteine excess triggers a mitochondrial iron-dependent cell death.Nature metabolism · 2026Article
- Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia-reperfusion injury in the heart.Nature metabolism · 2026Article
- Solute carrier membrane transporters: emerging targets in CNS disorders.Nature reviews. Drug discovery · 2026Review
- Glutathione Biology in Neurodegenerative and Metabolic Diseases: Molecular Mechanisms, Pathophysiological Roles, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Bioinformatic characterization of SLC25A39 across cancers with validation in hepatocellular carcinoma.Discover oncology · 2026Article
- Copper homeostasis and cuproptosis: molecular mechanisms and therapeutic opportunities.Molecular biomedicine · 2026Review
- Inhibition of ferroptosis via SLC25A39-NRF2 axis drives Osimertinib resistance in lung adenocarcinoma.Cellular and molecular life sciences : CMLS · 2026Article
- Technology-enabled insights into SLC transporters in MAFLD: redefining the multi-hit pathogenesis and therapeutic landscape.Acta pharmacologica Sinica · 2026Review
- Peroxisome Carrier SLC25A17: Potential Biomarker for Peroxisome Dysfunction and Human Disease.International journal of molecular sciences · 2026Review
- Dual-responsive polypyridyl Ru(II)-scaffolded hydrogel for trinitarian tumor therapy activated by mono-wavelength photo-irradiation.Journal of nanobiotechnology · 2026Article
- Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans.Redox biology · 2026Article
- Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue.bioRxiv : the preprint server for biology · 2026Article
- Glutathione in Our Diet and Its Role in the Body: From Disease Prevention to Anti-Aging.Nutrients · 2026Review
- Glutathione induces trap closure for carnivory in Cape sundew.Science advances · 2026Article
- Protopanaxatriol ameliorates diabetic retinopathy by regulating mTOR/G6PD mediated pentose phosphate pathway.Journal of natural medicines · 2026Article
- SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis.Nature cell biology · 2026Article
- Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains.Nature cell biology · 2026Article
101 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 3 institutions in 2 countries.
Ying Wang *Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Frederick S Yen *Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0001-7300-9370
Xiphias Ge Zhu *Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Rebecca C Timson *Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Ross WeberLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Changrui XingStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yuyang LiuLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Benjamin AllweinStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8756-4786
Hanzhi LuoMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hsi-Wen YehLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Søren HeisselThe Proteomics Resource Center, The Rockefeller University, New York, NY, USA.
Gokhan UnluLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2704-2724
Eric R GamazonDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4204-8734
Michael G KharasMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1165-6991
Richard HiteStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0496-0669
Kıvanç BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.ORCID http://orcid.org/0000-0002-7579-9895
Rockefeller University · USMemorial Sloan Kettering Cancer Center · USMRC Epidemiology Unit · GB
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MMechanisms of epitranscriptomic regulation in cancerR01CA186702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Michael Kharas · 2014 to 2026
$8.0MUncovering the role for MSI2 network in hematopoietic stem cellsR01DK101989 · NIDDK · SLOAN-KETTERING INST CAN RESEARCH · PI Michael Kharas, Vijay Ganesh Sankaran · 2014 to 2026
$6.2MCharacterizing the MSI2 network in leukemiaR01CA193842 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KHARAS, MICHAEL · 2015 to 2025
$4.1MIdentification of therapeutic targets for leukemia stem cells in AML-iPSC modelsR01CA225231 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KHARAS, MICHAEL, PAPAPETROU, EIRINI · 2018 to 2022
$3.2MMolecular and genetic analysis of novel Slicer-dependent miRNA pathways in bloodR01HL135564 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI KHARAS, MICHAEL, LAI, ERIC C · 2017 to 2020
$2.9MHaplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populationsR01GM140287 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI GAMAZON, ERIC R, MOHAMMADI, PEJMAN · 2021 to 2024
$2.8MDissecting tumor metabolic heterogeneity in vivoDP2CA228042 · NCI · ROCKEFELLER UNIVERSITY · PI BIRSOY, KIVANC · 2017 to 2017
$2.5MIdentification of metabolic regulators of glycerolipid synthesis and storageR01DK123323 · NIDDK · ROCKEFELLER UNIVERSITY · PI BIRSOY, KIVANC · 2019 to 2023
$2.5MFunctional Genomics: A Phenome-wide SurveyR35HG010718 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GAMAZON, ERIC R · 2019 to 2023
$2.2MNCATS NIH HHS UL1 TR001866NCI NIH HHS DP2 CA228042NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA186702NCI NIH HHS R01 CA193842NCI NIH HHS R01 CA225231NHGRI NIH HHS R01 HG011138NHGRI NIH HHS R35 HG010718NHLBI NIH HHS R01 HL135564NIDDK NIH HHS K99 DK128602NIDDK NIH HHS R01 DK101989NIDDK NIH HHS R01 DK123323NIGMS NIH HHS R01 GM140287NIGMS NIH HHS T32 GM007739NIH HHS 1R01 CA193842-01NIH HHS 1R01 CA193842-06A1NIH HHS 5R01 CA186702-07NIH HHS DP2 OD024174-01NIH HHS K99 DK128602-01NIH HHS R01 CA225231-01NIH HHS R01 DK101989-01A1NIH HHS R01-DK101989-06A1
Abstract
Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism
Indexed as
AnimalsBiological TransportCell ProliferationCells, CulturedErythropoiesisGlutathioneHomeostasisHumansIron-Sulfur ProteinsMiceMitochondriaMitochondrial Membrane Transport ProteinsOxidation-ReductionProteomeProteomicsGlutathioneIron-Sulfur ProteinsMitochondrial Membrane Transport ProteinsProteomeSLC25A39 protein, humanSlc25a39 protein, mouseSLC25A40 protein, human
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