Evidence map›Paper›PMID 34707244›Full record

ArticleCommunications biology2021

Characterizing the breast cancer lipidome and its interaction with the tissue microbiota.

Natasa Giallourou, Camilla Urbaniak, Scarlett Puebla-Barragan, Panagiotis A Vorkas, Jonathan R Swann, Gregor Reid

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 5 countries.

Natasa Giallourou *Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0001-5081-7367
Camilla Urbaniak *NASA Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA.
Scarlett Puebla-BarraganDepartment of Microbiology and Immunology, Western University, London, ON, Canada.
Panagiotis A VorkasDepartment of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0002-3523-0936
Jonathan R SwannDepartment of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, UK. j.swann@soton.ac.uk.ORCID 0000-0002-6485-4529
Gregor ReidDepartment of Microbiology and Immunology, Western University, London, ON, Canada.ORCID 0000-0001-9658-5696
Western University · CACentre for Research and Technology Hellas · GRJet Propulsion Laboratory · USUniversity of Cyprus · CYUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the most diagnosed cancer amongst women worldwide. We have previously shown that there is a breast microbiota which differs between women who have breast cancer and those who are disease-free. To better understand the local biochemical perturbations occurring with disease and the potential contribution of the breast microbiome, lipid profiling was performed on non-tumor breast tissue collected from 19 healthy women and 42 with breast cancer. Here we identified unique lipid signatures between the two groups with greater amounts of lysophosphatidylcholines and oxidized cholesteryl esters in the tissue from women with breast cancer and lower amounts of ceramides, diacylglycerols, phosphatidylcholines, and phosphatidylethanolamines. By integrating these lipid signatures with the breast bacterial profiles, we observed that Gammaproteobacteria and those from the class Bacillus, were negatively correlated with ceramides, lipids with antiproliferative properties. In the healthy tissues, diacylglyerols were positively associated with Acinetobacter, Lactococcus, Corynebacterium, Prevotella and Streptococcus. These bacterial groups were found to possess the genetic potential to synthesize these lipids. The cause-effect relationships of these observations and their contribution to disease patho-mechanisms warrants further investigation for a disease afflicting millions of women around the world.

Indexed as

LipidomicsMicrobiotaAdultAgedAged, 80 and overBacteriaBreastBreast NeoplasmsFemaleHumansMiddle AgedYoung Adult

Identifiers

PMID34707244
PMCPMC8551188
OpenAlexW3210194161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.