Evidence map›Paper›PMID 34707237›Full record

ArticleMolecular psychiatry2022

Sex differences in methylphenidate-induced dopamine increases in ventral striatum.

Peter Manza, Ehsan Shokri-Kojori, Corinde E Wiers, Danielle Kroll, Dana Feldman, Katherine McPherson, Erin Biesecker, Evan Dennis, Allison Johnson, Andrew Kelleher and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  8. Article
  9. Article
  10. Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Sex Differences in Histamine Regulation of Striatal Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  19. Review
  20. Neural basis for individual differences in the attention-enhancing effects of methylphenidate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Peter ManzaNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. peter.manza@nih.gov.ORCID http://orcid.org/0000-0002-0791-357X
Ehsan Shokri-KojoriNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6846-3173
Corinde E WiersNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Danielle KrollNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9624-504X
Dana FeldmanNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7676-5446
Katherine McPhersonNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6606-2410
Erin BieseckerNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Evan DennisNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Allison JohnsonNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Andrew KelleherNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Song QuDepartment of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2134-0226
Dardo TomasiNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0183-5678
Gene-Jack WangNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5017-9905
Nora D VolkowNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. nvolkow@nida.nih.gov.ORCID http://orcid.org/0000-0001-6668-0908
National Institutes of Health · US

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Intramural NIH HHS ZIA AA000550
6 · The paper itself

Abstract

Sex differences in the prevalence of dopamine-related neuropsychiatric diseases and in the sensitivity to dopamine-boosting drugs such as stimulants is well recognized. Here we assessed whether there are sex differences in the brain dopamine system in humans that could contribute to these effects. We analyzed data from two independent [

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsMethylphenidateVentral StriatumCorpus StriatumDopamineFemaleHumansMaleRacloprideSex CharacteristicsCentral Nervous System StimulantsDopamineMethylphenidateRaclopride

Identifiers

PMID34707237
PMCPMC9043036
OpenAlexW3210226858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.