SynthesisMolecular psychiatry2022
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Brain structure and function in adult survivors of developmental trauma with psychosis: A systematic review.Psychological medicine · 2025Pooled it
- Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study.Molecular psychiatry · 2026Article
- Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis.Molecular psychiatry · 2026Article
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations.Molecular psychiatry · 2026Article
- Altered lipid peroxidation, perineuronal net and oligodendrocyte markers in the frontal cortex of a dual-hit neurodevelopmental model support its relevance to schizophrenia.Frontiers in cellular neuroscience · 2026Article
- Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study.Biological psychiatry · 2025Article
- Latent Growth Models of Longitudinal Changes in Functional Connectivity during Early Stage Psychosis.Neuroinformatics · 2025Article
- Genome-Wide 5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Analysis of Plasma Cell-Free DNA in Schizophrenia.MedComm · 2025Article
- Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.Schizophrenia bulletin · 2025Article
- Differential Association of Schizotypy Dimensions With Brain Structural Connectivity and Moderation by Schizophrenia Polygenic Risk.Schizophrenia bulletin · 2025Article
- The Psychosis MRI Shared Data Resource (Psy-ShareD).Human brain mapping · 2025Article
- Functional Connectome Hierarchy in Schizotypy and Its Associations With Expression of Schizophrenia-Related Genes.Schizophrenia bulletin · 2024Article
- Schizotypal traits and their relationship to reading abilities in healthy adults.Schizophrenia research. Cognition · 2024Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow.Molecular psychiatry · 2024Article
- Large-Scale Neuroimaging of Mental Illness.Current topics in behavioral neurosciences · 2024Review
- A new causal centrality measure reveals the prominent role of subcortical structures in the causal architecture of the extended default mode network.Brain structure & function · 2023Article
- Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease.PLoS biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors at 20 institutions in 11 countries.
Matthias Kirschner *McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-9486-1439
Benazir Hodzic-Santor *McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.
Mathilde AntoniadesDepartment of Psychosis Studies, King's College London, London, UK.
Igor NenadicUniversity of Marburg, Marburg, Germany.
Tilo KircherUniversity of Marburg, Marburg, Germany.
Axel KrugUniversity of Marburg, Marburg, Germany.
Tina MellerUniversity of Marburg, Marburg, Germany.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Alex FornitoTurner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-0866-3477
Aurina ArnatkeviciuteTurner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.
Mark A BellgroveTurner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-0186-8349
Jeggan TiegoTurner Institute for Brain and Mental Health, School of Psychological Sciences and Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-7835-6398
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
Katharina KochDepartment of Psychiatry, University of Münster, Münster, Germany.
Carina HülsmannDepartment of Psychiatry, University of Münster, Münster, Germany.
Harald KugelUniversity Clinic for Radiology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-4349-1984
Verena EnnekingDepartment of Psychiatry, University of Münster, Münster, Germany.
Melissa KlugDepartment of Psychiatry, University of Münster, Münster, Germany.
Elisabeth J LeehrDepartment of Psychiatry, University of Münster, Münster, Germany.
Joscha BöhnleinDepartment of Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-9870-5599
Marius GruberDepartment of Psychiatry, University of Münster, Münster, Germany.
David MehlerDepartment of Psychiatry, University of Münster, Münster, Germany.
Pamela DeRosseDivision of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.ORCID http://orcid.org/0000-0003-0823-8163
Ashley MoyettDivision of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Melissa GreenSchool of Psychiatry, University of New South Wales (UNSW), Sydney, NSW, Australia.
Yann QuidéSchool of Psychiatry, University of New South Wales (UNSW), Sydney, NSW, Australia.
Christos PantelisMelbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-9565-0238
Raymond ChanInstitute of Psychology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-7571-6933
Yi WangInstitute of Psychology, Chinese Academy of Sciences, Beijing, China.
Ulrich EttingerUniversity of Bonn, Bonn, Germany.
Martin DebbanéUniversity of Geneva, Geneva, Switzerland.
Melodie DeromeUniversity of Geneva, Geneva, Switzerland.
Christian GaserJena University Hospital, Jena, Germany.
Bianca BesteherJena University Hospital, Jena, Germany.
Kelly DiederenDepartment of Psychosis Studies, King's College London, London, UK.
Tom J SpencerDepartment of Psychosis Studies, King's College London, London, UK.
Paul FletcherDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Wulf RösslerPsychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Lukasz SmigielskiPsychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Veena KumariBrunel University London, Uxbridge, UK.ORCID http://orcid.org/0000-0002-9635-5505
Preethi PremkumarBrunel University London, Uxbridge, UK.
Haeme R P ParkSchool of Psychology, University of Auckland, Auckland, New Zealand.
Kristina WiebelsSchool of Psychology, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-5360-5965
Imke Lemmers-JansenFree University, Amsterdam, the Netherlands.
James GilleenDepartment of Psychosis Studies, King's College London, London, UK.
Paul AllenUniversity of Roehampton, London, UK.
Petya KozhuharovaUniversity of Roehampton, London, UK.
Jan-Bernard MarsmanDepartment of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Irina LebedevaMental Health Research Center, Moscow, Russian Federation.
Alexander TomyshevMental Health Research Center, Moscow, Russian Federation.
Anna MukhorinaMental Health Research Center, Moscow, Russian Federation.ORCID http://orcid.org/0000-0003-2369-5493
Stefan KaiserDepartment of Psychiatry, Geneva University Hospital, Geneva, Switzerland.
Anne-Kathrin FettDepartment of Psychosis Studies, King's College London, London, UK.
Iris SommerDepartment of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Sanne Schuite-KoopsDepartment of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Casey PaquolaMcConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.
Sara LarivièreMcConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0001-5701-1307
Boris BernhardtMcConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.
Alain DagherMcConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-0945-5779
Phillip GrantFresenius University of Applied Sciences, Frankfurt am Main, Germany.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-2465-2797
Jessica A TurnerImaging Genetics and Neuroinformatics Lab, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-0076-8434
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
André AlemanDepartment of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Gemma ModinosDepartment of Psychosis Studies, King's College London, London, UK. gemma.modinos@kcl.ac.uk.ORCID http://orcid.org/0000-0002-7870-066X
University of Münster · DEMontreal Neurological Institute and Hospital · CAKing's College London · GBMonash University · AUUniversity Medical Center Groningen · NLMental Health Research Center of Russian Academy of Medical Sciences · RUPhilipps University of Marburg · DEBrunel University of London · GBInstitute of Psychology, Chinese Academy of Sciences · CNJena University Hospital · DENorthwell Health · USThe University of Melbourne · AUUniversity of Auckland · NZUniversity of Bonn · DEUniversity of Geneva · CHUniversity of Roehampton · GBUNSW Sydney · AUCity, University of London · GBGeorgia State University · USHochschule Fresenius · DE
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MNIBIB NIH HHS U54 EB020403Wellcome Trust 202397/Z/16/Z
Abstract
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, p
Indexed as
Bipolar DisorderPsychotic DisordersSchizophreniaSchizotypal Personality DisorderFemaleHumansMagnetic Resonance ImagingMale
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.