ArticleScientific reports2021
Involvement of the habenula in the pathophysiology of autism spectrum disorder.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Evaluation of Risk of Bias in Neuroimaging-Based Artificial Intelligence Models for Psychiatric Diagnosis: A Systematic Review.JAMA network open · 2023Pooled it
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Habenula Alterations in Resting-State Functional Connectivity Among Autistic Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Lateral Habenula 5-HT₂A Receptors Mediate Social Deficits in a Valproic Acid-Induced Rodent Model of Autism Spectrum Disorder.Molecular neurobiology · 2026Article
- Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles.Molecular autism · 2026Article
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders.Molecular neurobiology · 2025Review
- Disrupted functional connectome in a rodent model of autism during social isolation.Frontiers in neural circuits · 2025Article
- Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury.Pharmacology, biochemistry, and behavior · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Diencephalic organoids - A key to unraveling development, connectivity, and pathology of the human diencephalon.Frontiers in cellular neuroscience · 2023Review
- Habenula as a Neural Substrate for Aggressive Behavior.Frontiers in psychiatry · 2022Review
- Editorial: The Habenula and Its Role in Neuropsychiatric Symptoms.Frontiers in behavioral neuroscience · 2022Article
- Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications.Frontiers in behavioral neuroscience · 2022Review
- Habenular Involvement in Response to Subcallosal Cingulate Deep Brain Stimulation for Depression.Frontiers in psychiatry · 2022Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Autism spectrum disorder (ASD) is characterized by social communication deficits, restricted interests, repetitive behaviors, and is frequently associated with altered sensory perception and mood and sleep disorders. The habenula is implicated in all these behaviors and results of preclinical studies suggest a possible involvement of the habenula in the pathophysiology of this disorder. Using anatomical magnetic resonance imaging and automated segmentation we show that the habenula is significantly enlarged in ASD subjects compared to controls across the entire age range studied (6-30 years). No differences were observed between sexes. Furthermore, support-vector machine modeling classified ASD with 85% accuracy (model using habenula volume, age and sex) and 64% accuracy in cross validation. The Social Responsiveness Scale (SRS) significantly differed between groups, however, it was not related to individual habenula volume. The present study is the first to provide evidence in human subjects of an involvement of the habenula in the pathophysiology of ASD.
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