ReviewBone research2021
Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors.
Review in Bone research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A Fully Defined GelMA-Based Matrix Allows Fine Tuning of Tissue-Relevant Biomechanical and Biochemical Cues for Organoid Culture.Advanced healthcare materials · 2026Article
- Stepwise micro-CT analysis of sample processing effects on the 3D morphology of human intervertebral discs.Osteoarthritis and cartilage open · 2026Article
- High-Throughput Label-Free Continuous Quantification of Muscle Stem Cell Proliferation and Myogenic Differentiation.Stem cell reviews and reports · 2025Article
- Enhanced Bioactivity of Chitosan-Alginate-Riboflavin Liquid-Exfoliated Molybdenum Disulfide Nanosheets for Bone Tissue Engineering Applications.ACS omega · 2024Article
- Understanding the Structure-Function Relationship through 3D Imaging and Biomechanical Analysis: A Novel Methodological Approach Applied to Anterior Cruciate Ligaments.Biomimetics (Basel, Switzerland) · 2024Article
- Enabling 3D bioprinting of cell-laden pure collagen scaffolds via tannic acid supporting bath.Frontiers in bioengineering and biotechnology · 2024Article
- Enhancement of Scaffold In Vivo Biodegradability for Bone Regeneration Using P28 Peptide Formulations.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Characterization of Biocompatibility of Functional Bioinks for 3D Bioprinting.Bioengineering (Basel, Switzerland) · 2023Review
- Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications.Advanced healthcare materials · 2023Review
- Nanotechnology-Enabled Biosensors: A Review of Fundamentals, Design Principles, Materials, and Applications.Biosensors · 2022Review
- Effect of glucose depletion and fructose administration during chondrogenic commitment in human bone marrow-derived stem cells.Stem cell research & therapy · 2022Article
- Article
- Microcarriers in application for cartilage tissue engineering: Recent progress and challenges.Bioactive materials · 2022Review
- Author Correction: Quality control methods in musculoskeletal tissue engineering: from imaging to biosensors.Bone research · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Funding
Abstract
Tissue engineering is rapidly progressing toward clinical application. In the musculoskeletal field, there has been an increasing necessity for bone and cartilage replacement. Despite the promising translational potential of tissue engineering approaches, careful attention should be given to the quality of developed constructs to increase the real applicability to patients. After a general introduction to musculoskeletal tissue engineering, this narrative review aims to offer an overview of methods, starting from classical techniques, such as gene expression analysis and histology, to less common methods, such as Raman spectroscopy, microcomputed tomography, and biosensors, that can be employed to assess the quality of constructs in terms of viability, morphology, or matrix deposition. A particular emphasis is given to standards and good practices (GXP), which can be applicable in different sectors. Moreover, a classification of the methods into destructive, noninvasive, or conservative based on the possible further development of a preimplant quality monitoring system is proposed. Biosensors in musculoskeletal tissue engineering have not yet been used but have been proposed as a novel technology that can be exploited with numerous advantages, including minimal invasiveness, making them suitable for the development of preimplant quality control systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.