Evidence map›Paper›PMID 34707053›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Bilateral Serous Retinal Detachment Associated with a Mitogen-activated Protein KinaseKinase Inhibitor in a Patient with BRAF-mutant Colorectal Cancer.

Miho Sakumura, Takayuki Ando, Tomoko Ueda-Consolvo, Iori Motoo, Hiroshi Mihara, Shinya Kajiura, Akira Teramoto, Sohachi Nanjo, Haruka Fujinami, Ichiro Yasuda

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Miho SakumuraThird Department of Internal Medicine, Toyama University Hospital, Japan.
Takayuki AndoThird Department of Internal Medicine, Toyama University Hospital, Japan.
Tomoko Ueda-ConsolvoDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Iori MotooThird Department of Internal Medicine, Toyama University Hospital, Japan.
Hiroshi MiharaThird Department of Internal Medicine, Toyama University Hospital, Japan.
Shinya KajiuraThird Department of Internal Medicine, Toyama University Hospital, Japan.
Akira TeramotoThird Department of Internal Medicine, Toyama University Hospital, Japan.
Sohachi NanjoThird Department of Internal Medicine, Toyama University Hospital, Japan.
Haruka FujinamiThird Department of Internal Medicine, Toyama University Hospital, Japan.
Ichiro YasudaThird Department of Internal Medicine, Toyama University Hospital, Japan.
Toyama University Hospital · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a 73-year-old woman with BRAF V600E-mutated colon cancer treated with encorafenib plus cetuximab with binimetinib as standard salvage therapy for patients with advanced colorectal cancer. She developed bilateral serous retinal detachment the next day, and the regimen was discontinued, resulting in complete resolution by the third day. Doublet therapy without binimetinib was initiated along with a weekly ophthalmologic examination for 10 weeks without recurrence of retinal detachment. Thus, binimetinib was presumed to have been the cause of the retinal detachment. This clinical course suggests the need for close monitoring of patients for vision impairment and close collaboration with ophthalmologists.

Indexed as

Colorectal NeoplasmsRetinal DetachmentAgedCarbamatesFemaleHumansIntercellular Signaling Peptides and ProteinsMitogensMutationProto-Oncogene Proteins B-rafSulfonamidesBRAF protein, humanCarbamatesIntercellular Signaling Peptides and ProteinsMitogensProto-Oncogene Proteins B-rafSulfonamidesBRAFcolorectal cancerMEK inhibitorretinal detachment

Identifiers

PMID34707053
PMCPMC9259315
OpenAlexW3208176968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.