Evidence map›Paper›PMID 34707037›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2021

t(9;14)(p13;q32)/PAX5-IGH translocation as a secondary cytogenetic abnormality in diffuse large B-cell lymphoma.

Hitoshi Ohno, Kayo Takeoka, Chiyuki Kishimori, Miho Nakagawa, Katsuhiro Fukutsuka, Fumiyo Maekawa, Masahiko Hayashida, Takashi Akasaka, Shinji Sumiyoshi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hitoshi OhnoTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Kayo TakeokaTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Chiyuki KishimoriTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Miho NakagawaTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Katsuhiro FukutsukaTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Fumiyo MaekawaTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Masahiko HayashidaTenri Institute of Medical Research, Tenri Hospital, Nara, Japan.
Takashi AkasakaDepartment of Hematology, Tenri Hospital, Nara, Japan.
Shinji SumiyoshiDepartment of Diagnostic Pathology, Tenri Hospital, Nara, Japan.
Tenri Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 75-year-old man presented with an ileocecal tumor composed of diffuse proliferation of large cells with immunoblastic morphology. Lymphoma cells were positive for CD20, CD79a, IRF4/MUM1, and BCL2, negative for CD5, CD10, and MYC, and partially positive for BCL6. PAX5 was positive with variable staining intensity among the cell nuclei. The V-D-J sequence of IGH showed the mutated configuration. The G-banding karyotype demonstrated two cytogenetic clones with or without t(9;14)(p13;q32), but the two shared other structural and numerical abnormalities. Fluorescence in situ hybridization using PAX5 and IGH probes confirmed the presence or absence of t(9;14)(p13;q32)/PAX5-IGH in each clone. The breakpoints of t(9;14)(p13;q32) were mapped 2,170 bp upstream of the coding region of PAX5 alternative exon 1B and within the IGHJ6-Eμ enhancer intron of IGH. It is suggested that t(9;14)(p13;q32) in this case was a secondary cytogenetic abnormality and the translocation is not necessarily involved in initial malignant transformation of B-cells but can occur later during the course of diffuse large B-cell lymphoma.

Indexed as

DNA-Binding ProteinsLymphoma, Large B-Cell, DiffuseAgedCell Transformation, NeoplasticChromosomes, Human, Pair 14HumansIn Situ Hybridization, FluorescenceMalePAX5 Transcription FactorTranslocation, GeneticDNA-Binding ProteinsPAX5 protein, humanPAX5 Transcription Factor14)(p13diffuse large B-cell lymphoma, non-GCB/ABC phenotype, t(9q32) translocation, secondary cytogenetic abnormality, PAX5 gene

Identifiers

PMID34707037
PMCPMC8808109
OpenAlexW3210393685

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.