ArticleNeurology2021
Burden of Chronic and Acute Conditions and Symptoms in People With Epilepsy.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea.Epilepsia open · 2026Article
- An epilepsy prediction and management system based on federated learning combined with hybrid harmony search and mutual information (HAS-MI)-based feature selection approach.Scientific reports · 2025Article
- Global, regional and national burden of epilepsy in adolescents aged 10-19 years from 1990 to 2021: An analysis for the Global Burden of Disease Study 2021.Epilepsia open · 2025Article
- Is Cardiovascular Mortality Among People with Epilepsy increasing? A retrospective US population study.BMJ open · 2025Article
- Factors Affecting Sleep and Wakefulness in People with Epilepsy: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Analysis of the Correlation between Frailty Index, Clinical Characteristics, Use of Anti-Epileptic Drug, and Prognosis in Elderly Patients with Epilepsy.Actas espanolas de psiquiatria · 2025Article
- Comorbidity Among Adults With Epilepsy - United States, 2021-2022.Preventing chronic disease · 2024Article
- A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy.Epilepsia open · 2024Article
- Mortality and mortality disparities among people with epilepsy in the United States, 2011-2021.Epilepsy & behavior : E&B · 2024Article
- Increased cardiovascular risk in epilepsy.Frontiers in neurology · 2024Review
- Disparities in adherence and emergency department utilization among people with epilepsy: A machine learning approach.Seizure · 2023Article
- Racial and Ethnic Differences in Antiseizure Medications Among People With Epilepsy on Medicaid: A Case of Potential Inequities.Neurology. Clinical practice · 2023Article
- Should neurologists initiate treatment for hypertension and hyperlipidemia to reduce cardiovascular risk in epilepsy?Frontiers in neurology · 2023Article
- A framework for health equity in people living with epilepsy.Epilepsy research · 2022Review
- Incidence of and predictors for antiseizure medication gaps in Medicare beneficiaries with epilepsy: a retrospective cohort study.BMC neurology · 2022Article
- Author Response: Burden of Chronic and Acute Conditions and Symptoms in People with Epilepsy.Neurology · 2022Article
- Variation in multimorbidity by sociodemographics and social drivers of health among patients seen at community-based health centers.Journal of multimorbidity and comorbidityArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesPeople with epilepsy, one-third of whom in the United States are on Medicaid, experience a wide range of chronic and physical comorbidities that influence their care and outcomes. In this study, we examine the burden and racial/ethnic disparities of chronic and acute conditions, injuries, and symptoms in a large and diverse group of people with epilepsy on Medicaid.
methodsUsing 5 years of Medicaid claims data, we identified adults with epilepsy and used all available claims and diagnoses to identify each person's Clinical Classification Codes groups diagnosed during the study period. Using association rule mining, we identified the top combinations of conditions and stratified these by race/ethnicity to identify potential prevalence disparities. We examined the top combinations of conditions in high utilizers; that is, individuals in the top quartile of hospitalizations and emergency department visits.
resultsAmong 81,963 patients, the most common conditions were anxiety and mood disorders (46.5%), hypertension (36.9%), back problems (35.2%), developmental disorders (31.6%), and headache (29.5%). When examining combinations of conditions, anxiety and mood disorders continued to have an outsized prevalence, appearing in nearly every combination. There were notable disparities in disease burden, with American Indians and Alaskan Natives having a substantially higher prevalence of developmental disorders, while Black individuals had a higher prevalence of hypertension. These disparities persisted to the higher-order combinations that included these conditions. High utilizers had a much higher disease burden, with 75.8% having an anxiety or mood disorder, as well as a higher burden of injuries. DISCUSSION: This study shows a high prevalence of psychiatric and physical conditions and identifies racial and ethnic disparities affecting people with epilepsy. Targeting interventions to consider the comorbidities, race, and ethnicity has potential to improve clinical care and reduce disparities.
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